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116076 trials found · Page 5192 of 5804
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Pollution may worsen pregnancy dangers for heart patients
Knowledge-focused CompletedWith economic development and rapid urbanization, air pollution has become an increasingly severe public health concern. The risk of adverse pregnancy outcomes is significantly elevated for pregnant women complicated by pulmonary hypertension. However, no studies to date have spe…
Sponsor: Wei Huang • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:16 UTC
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Could a smarter chemo schedule help kids beat cancer?
Disease control CompletedThe subject is invited to take part in this research study because s/he has been diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL), Primary Mediastinal B-cell Lymphoma (PMBCL), or Post-transplant Lymphoproliferative Disorder (PTLD). In an attempt to improve cure rates while r…
Phase: EARLY_PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Global PCD data pool aims to unlock secrets of rare lung disease
Knowledge-focused OngoingThe iPCD Cohort is an international cohort that assembles available retrospective datasets and prospectively newly collected clinical and diagnostic data from patients suffering from primary ciliary dyskinesia (PCD) worldwide, to answer pertinent questions on clinical phenotype, …
Sponsor: University of Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Researchers hunt for clues to predict spine arthritis progression
Knowledge-focused CompletedSpondyloarthritis refers to a set of inflammatory disorders that mainly afflict the spine, joints and ligaments. A subtype of spondyloarthritis is Ankylosing Spondylitis - now known as axial spondyloarthropathy - which is characterized by inflammation of the joints in the spinal …
Sponsor: Hospital for Special Surgery, New York • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Preemie formula study: does extra vitamin d build stronger bones?
Knowledge-focused CompletedTransitional formulas (22 kcal/oz) are recommended for infants less than 35 weeks gestation at birth. However, few data are available related to follow-up of infants receiving these formulas who were 28-34 weeks gestation at birth. Primary hypothesis: Provision of supplemental v…
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Can a meaning-centered group help breast cancer survivors find purpose?
Symptom relief OngoingThe purpose of this study is to compare two types of groups for breast cancer survivors: a Meaning-Centered Group and a Discussion Group. Many breast cancer survivors seek help to deal with the emotional burden of having gone through the cancer experience. Participation in groups…
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Massive PAD registry aims to settle stent vs Non-Stent debate
Knowledge-focused Recruiting nowXLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients. The study will create a registry that will include entry of procedural and clinical follow-up information into an online data collection softw…
Sponsor: Baylor Research Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Inner ear secrets: study aims to predict who will hear better with hearing aids
Knowledge-focused CompletedUnderstanding speech is essential for good communication. Individuals with hearing loss and poor speech discrimination often have little success with hearing aids because amplifying sound improves audibility, but not clarity of the speech signal. The purpose of this study is to d…
Sponsor: Steward St. Elizabeth's Medical Center of Boston, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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30,000 heart patients enrolled in major risk factor study
Knowledge-focused Recruiting nowThis study is a single-center, historical prospective cohort study including patients diagnosed with coronary artery diseases, including stable angina pectoris, unstable angina pectoris, non-ST-segment elevation myocardial infarction, ST-segment elevation myocardial infarction, l…
Sponsor: Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Lupus Patients' Pill-Taking habits under the microscope
Knowledge-focused CompletedThe treatment of systemic lupus erythematosus (SLE) may change in the future due to the availability of new biological treatments, especially monoclonal antibodies in patients with active disease. However, one of the main causes of treatment failure in SLE is the lack of treatmen…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Scientists hunt for clues in colorectal cancer tissue and blood
Knowledge-focused Recruiting now* A prospective, observational study on clinical outcomes of surgical management of primary and metastatic colorectal cancer * Prospective collection of tissues to explore potential biomarkers in blood and/or primary or secondary cancers and/or normal colon
Sponsor: Helse Stavanger HF • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC
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Cash for clean breath: new program helps homeless veterans quit smoking
Symptom relief CompletedThe purpose of this study is to examine the effectiveness of an internet-based contingency management program for smoking cessation in persons who are homeless. Thirty homeless smokers will be enrolled in the study. Participants will receive payment based on their own low carbon …
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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New study aims to predict dangerous bleeding during weight-loss surgery
Knowledge-focused CompletedAs bleeding is a major risk in bariatric surgeries, The study aimed to find any predictors to such bleeding within the surgery or 30 days after surgery. The study is a retrospective study collecting patients data, surgeons data, and hospitals data in order to find if any of the f…
Sponsor: Assuta Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Vitamin d deficiency common in heart failure patients – does supplementation help?
Knowledge-focused CompletedPatients will undergo at baseline and regular intervals: * clinically indicated bloodwork/urine and echocardiogram testing * biomarker studies Upon enrolment in the study patients will be divided into 4 groups normal, mildly deficient and severely deficient. Normal and mild vit…
Phase: PHASE4 • Sponsor: Ottawa Heart Institute Research Corporation • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Blood pressure experiment in sepsis halted early – kidney protection still unclear
Knowledge-focused TerminatedSepsis is the most severe complication of infections. Sepsis-associated Acute kidney injury (AKI) is commonly encountered in critically ill patients and independently predicts poor outcome. Unfortunately, no drug or management strategy was able to reduce incidence of AKI. To adap…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Obesity linked to higher kidney stone risk, study finds
Knowledge-focused CompletedThe goal of this study is to determine if obesity is associated with increased endogenous oxalate synthesis as assessed by urinary oxalate excretion, which is a known risk factor for calcium oxalate kidney stones. The study will recruit adult participants without history of kidn…
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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New hip implant technique shows promise in revision surgery
Disease control CompletedTotal hip arthroplasty (THA) requires bone reconstruction in case of severe acetabular injury, with risk of dislocation, especially postoperatively. Dual-mobility cups have proved effective in preventing dislocation in THA revision for instability, but their behavior when cemente…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Can a pharmacy bundle shorten ICU stays and cut costs?
Knowledge-focused CompletedThe aim of this before-after study was to assess the impact of a clinical pharmacy bundle of care activities on patient outcomes (length of hospital stay as a primary endpoint) and cost expenditure in two French ICUs.
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Psoriasis Drug's skin gene secrets revealed in small trial
Knowledge-focused CompletedThe expertise in the characterization of transcriptomics profile in lesional psoriatic skin and on the availability of innovative therapy for these patients.The investigators propose to follow the modification of the skin transcriptomics profile in psoriatic patients during succe…
Phase: PHASE2 • Sponsor: Poitiers University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Women may face higher risks after aortic aneurysm repair, study suggests
Knowledge-focused CompletedThe aim of our study is to analyze the early and late results in men and women who underwent ascending aortic replacement in antegrade cerebral perfusion (ACP) with mild-to-moderate hypothermic circulatory arrest. Female gender is associated with poorer outcomes after surgical ao…
Sponsor: Tomsk National Research Medical Center of the Russian Academy of Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC