Could a smarter chemo schedule help kids beat cancer?
NCT ID NCT01760226
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tested a chemotherapy regimen called DA-EPOCH-R in 4 children with certain B-cell cancers (DLBCL, PMBCL, or PTLD). The drugs are given as a continuous infusion over several days, and doses are adjusted based on how the child's body handles them. The goal was to see if this approach is safe and could improve cure rates while reducing side effects, as it has in adults.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- DA-EPOCH-R (a combination of rituximab, etoposide, vincristine, doxorubicin, cyclophosphamide, prednisone, and G-CSF)
- What this could lead to
- If this approach works in children, it could offer a safer and more effective treatment for certain B-cell cancers, potentially reducing side effects while maintaining high cure rates.
- What could go wrong
- This is a very early, small study with only 4 participants, so results may not apply to all children. The safety and effectiveness in children are still unknown, and there are risks from chemotherapy like infections and mouth sores.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Texas Children's Hospital
Houston, Texas, 77030, United States
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