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127005 trials found · Page 5143 of 6351
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Weight loss before knee surgery shows promise in small trial
Symptom relief CompletedObesity, specifically BMIs ≥35 or 40 kg/m2, are associated with an increased probability of poor outcomes of Total Knee Arthroplasty (TKA) including increased pain, risk for infection, poor joint function, and increased rates of hospital readmissions. Several orthopedic and publi…
Sponsor: University of Kansas Medical Center • Aim: Symptom relief
Last updated Jun 26, 2026 18:45 UTC
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Brain scans reveal how anti-vaping ads may curb e-cigarette use in young black adults
Knowledge-focused Completed60 young adult African American vapers who are not current smokers will participate in a baseline functional magnetic resonance imaging (fMRI) experiment, with 4 weekly follow-up surveys to gauge their tobacco use behaviors following the baseline scan. Baseline fMRI tasks will pr…
Sponsor: University of Georgia • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Virtual navigation program aims to ease insurance confusion for childhood cancer survivors
Knowledge-focused OngoingThe investigators are conducting a Type I hybrid effectiveness-implementation trial to assess the effectiveness of HINT-S (synchronous) compared to enhanced usual care (EUC) in promoting health insurance literacy, thus reducing worry, unmet health care needs, and financial conseq…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Can better genetic education help men fight prostate cancer?
Knowledge-focused Recruiting nowWith this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions. This study is designed to investigate the understanding of prognostic genetic technology in African American and rural White men at …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC
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Researchers hunt for clues to who benefits from back pain injections
Knowledge-focused CompletedSacroiliac joint (SIJ) pain is one of the underappreciated causes of low back pain. Recent studies have reported excellent outcomes after Ultrasound (US) guided SIJ injection with local anesthetics and corticosteroids, but these studies are characterized by wide variability in se…
Sponsor: Alexandria University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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AI could spot severe asthma patients faster, study says
Knowledge-focused OngoingThe study aims to to use new technologies (ML, AI, NLP), to autonomously identify moderate to severe asthma populations within an EHR system, describe differences in treatment patterns across different populations, and determine trial eligibility. Primary Objectives Please ensur…
Sponsor: San Diego State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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New online platform aims to help young adults navigate genetic cancer risks
Knowledge-focused OngoingThis research is being done to develop the electronic platform Nest for young adults (ages 18-39) who have had prior cancer genetic testing. The platform will give patients and their clinicians access to continuously updated information about both pathogenic variants and variants…
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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New reading strategy boosts comprehension for young adults with disabilities
Knowledge-focused CompletedThe purpose of this study is to evaluate the effects of a written language intervention using functional texts for young adults with intellectual and developmental disabilities.
Sponsor: Baylor University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Which Mucus-Clearing device works best? new study aims to find out
Symptom relief Recruiting nowThis pilot study aims to compare the ability of a higher oscillatory index device versus a lower oscillatory index device on airway secretion clearance and other clinically significant outcomes.
Sponsor: Rush University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Can a smartphone app help liver patients avoid emergencies?
Knowledge-focused CompletedThe goal of this multicenter feasibility study is to investigate the feasibility of our telemedicine platform (myLIVERcoach) in liver cirrhosis patients, according to liver cirrhosis patients, caregivers and healthcare professionals. The main question\[s\] it aims to answer are: …
Sponsor: Maastricht University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Phone support boosts diabetes Self-Care in new study
Disease control CompletedThis study examined the effects of self-management education combined with follow-up telephone support on diabetes self-management, treatment compliance, and medication self-efficacy in adults with Type 2 diabetes. A total of 70 adults with type 2 diabetes were randomly assigned …
Sponsor: Selcuk University • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Simple hand exercises may boost brain power in kids with learning disorder
Symptom relief CompletedThe goal of this semi-experimental study is to investigate whether bilateral (limbs of both sides of the body, such as left and right hands) perceptual-motor (PM) exercises and unilateral (limb of only one side of the body, such as only the left hand) PM exercises affect manual d…
Sponsor: Allameh Tabatabai University • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Can a magnetic helmet sharpen memory in early Alzheimer's?
Knowledge-focused Recruiting nowIn this research study we want to learn more about the effects of non-invasive brain stimulation on memory and brain-network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive…
Early phase 1 • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Promising CAR-T therapy for tough blood cancers hits snag – study withdrawn
Disease control CancelledThis study is a single arm, non blind, randomized, single center study aimed at evaluating the safety, pharmacokinetic characteristics, and preliminary efficacy of CD7 CAR-T cell injection in r/r T-ALL/LBL subjects.
Phase 1/2 • Sponsor: Guangzhou Bio-gene Technology Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Hormone combo tested for clues to appetite and energy control
Knowledge-focused Recruiting nowThis is a randomized, placebo-controlled, cross-over study with 4 arms. Healthy and GH deficient adults ages 18-45 years will be studied. Arms will consist of 21-day treatment periods and be separated by 8-week washout periods. Subjects will receive, in random order: i) GH alone,…
Phase 4 • Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can balance exercises keep COPD seniors on their feet?
Symptom relief CompletedThe aim of the study will be to verify whether the addition of an exercise program aimed to improve balance can reduce the risk of falling in subjects with COPD over 80 years of age compared to the standard rehabilitation program. Patients will be randomly assigned in two groups …
Sponsor: Istituti Clinici Scientifici Maugeri SpA • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Gum surgery recovery boosted by Platelet-Rich fibrin and hyaluronic acid?
Disease control CompletedObjectives: This study aimed to evaluate the effect of injectable platelet-rich fibrin (i-prf), titanium-prepared platelet-rich fibrin (t-prf), and 0.8% hyaluronic acid (HA) gel on clinical periodontal parameters, wound healing, patient comfort and satisfaction after gingivectomy…
Sponsor: Saglik Bilimleri Universitesi • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Krill power: could this tiny creature help seniors build stronger muscles?
Disease control CompletedThe aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building proc…
Sponsor: University of Glasgow • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Which pain block works best for hernia repair? small study seeks answers
Symptom relief CompletedThis study aimed to compare the analgesic efficacy of the external oblique intercostal fascial plane block (EOIPB) versus the rectus sheath block (RSB) for managing postoperative pain following paraumbilical hernioplasty.
Phase 3 • Sponsor: Helwan University • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Brain scans aim to unlock secrets of chronic pain in kids
Knowledge-focused Recruiting nowThe goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediat…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:02 UTC