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This clinical trial evaluates whether continuing or withholding ACE inhibitors (specifically Ramipril) before coronary angiography affects the risk of contrast-induced nephropathy (CIN). CIN is a known complication of iodinated contrast exposure, particularly in patients with chr…

This study is part of the Clinnova program. This is a prospective cohort study including patients with IBD recruited at the time of a treatment change. At least 800 participants (recruited in France, Germany and Luxembourg) will be enrolled, of which 100 participants are expecte…

The goal of this longitudinal observational study is to learn the course of recovery after stroke. Specifically, in this study we will learn and describe the changes in cognitive, motor and sensory function over time in stroke patients.

Urodynamic testing (UDT) is a diagnostic procedure frequently used to evaluate lower urinary tract dysfunction, including urinary incontinence and voiding difficulties. Despite its diagnostic value, UDT is invasive and often causes discomfort, pain, and embarrassment due to cathe…

In the Netherlands, breast cancer patients with locoregional recurrence (LRR) and intermediate- and high-risk factors are treated with surgery with or without postoperative re-irradiation with or without hyperthermia. Retrospective studies showed that 3-year locoregional control …

Breast surgeries are common operative procedures that require appropriate postoperative analgesia.

Single centre observational study to assess lower extremity arterial disease (LEAD) patients' cardiac dysfunction with strain analyses and to assess connections between cardiac dysfunction, metabolomic changes and target organ damage in LEAD.

This study aim is to assess, if treosulfan pharmacokinetics are influenced by declined renal function and by race/ethnicity of patients. The study also aims to determine an appropriate safe dose of treosulfan, when patient's renal function is impaired. The participants of this st…

CLIC-YYC-GPNMB-02 is a Single Patient Study (SPS) developed according to the Health Canada template and guidelines released in 2019 for studies to access therapies not otherwise available to patients, in the situation where there are no options of treatment or cure remaining. The…

The goal of this clinical trial is to examine the effectiveness of a structured stress management intervention in promoting healthier coping mechanisms and reducing perceived stress levels among emotionally abused young women. The main questions it aims to answer are: H1: Women …

General Aim: to explore the iKA in TKA related to clinical, biomechanical, and functional outcomes.

Disability involves limitations that affect mobility and the ability to perform daily activities and achieve competitive goals. It is expected that disability has a significant impact on body composition, including reductions in lean mass and bone mineral content, and increases i…

This study examines whether an exercise-based simulation can reduce weight bias and improve professional skills among health professions students. Weight stigma in healthcare settings can negatively affect patient communication, clinical decision-making, and patient engagement in…

This study will examine whether a home-based rehabilitation program can help older adults recover after surgery for a hip fracture. The program is delivered by a specialized "Hospital-at-Home" unit, which provides hospital-level care in the patient's home. Participants in this s…

This study aimed to compare the development of the uterine niche after single and double closure of cesarean incision.

The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.

This study aims to evaluate the effectiveness of an innovative psychiatric nursing intervention in reducing caregiver burden and enhancing psychological resilience and positive emotional outcomes among family caregivers of patients with bipolar disorder. Family caregivers often e…

This randomized controlled trial evaluates the effectiveness of postoperative topical antibiotics compared with oral antibiotics in patients undergoing surgical extraction of impacted mandibular third molars. The study aims to compare postoperative outcomes including infection, d…

The purpose of this study is to determine the effect of herbal pillows on sleep and quality of life in a healthy population using actigraphy, validated questionnaires and daily diary logs. The goal of this study is to improve sleep and quality of life using herbal and Ayurveda/ho…

The aim of this clinical trial is : To evaluate effect of different techniques of irrigant activation: 1. LASER activation 2. sonic activation 3. ultrasonic activation 4. passive needle irrigation On: 1. Postoperative pain in vital teeth (Randomized controlled trial) 2. Amoun…