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127005 trials found · Page 4218 of 6351
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Which Hand-On fix works best for pelvic pain? new trial aims to find out
Symptom relief Not yet recruitingThe purpose of this study is to evaluate the comparative effects of Innominate Rotation Correction and Sacral Torsion Correction using Muscle Energy Techniques (METs) in patients with Sacroiliac Joint Dysfunction (SIJD). A total of 50 participants will be recruited, aged 18-50 yr…
Sponsor: Foundation University Islamabad • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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New obesity drug LAE103 enters first human safety trials
Disease control Recruiting nowThe purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of LAE103 injection in healthy overweight/obese participants or healthy postmenopausal women. Study will also evaluate the safety, tolerability and preliminary pharmacodynamic effect of multipl…
Phase 1 • Sponsor: Laekna Limited • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Lupus blood test clues: tiny molecules under the microscope
Knowledge-focused Not yet recruitingSystemic lupus erythematosus (SLE) is a complex autoimmune disease affecting multiple organs and characterized by heterogeneous clinical manifestations. This case-control study aims to assess the association between serum expression levels of MicroRNA-101-3p and Autotaxin (ATX) i…
Sponsor: Eman Mohamed Shawky • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Vitamin d may ease braces pain and speed up tooth movement
Symptom relief Not yet recruitingThe goal of this interventional research is to determine the impact of vitamin D intake on substances in saliva, pain, tooth movement, and the density of the bone around teeth in patients during orthodontic treatment. It will compare the effects of vitamin D supplementation with …
Sponsor: Hospital Universiti Sains Malaysia • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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New smartphone program aims to help lung disease patients at home
Knowledge-focused Not yet recruitingThis study analyzes the needs of patients regarding the content and form of home-based health education through interviews, and constructs a health education program tailored to these needs. A practical WeChat mini-program is developed to enable patients with interstitial lung di…
Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Which score saves lives? new study tests chest trauma prediction tools
Knowledge-focused Not yet recruitingThis study aim to compare the effectiveness of the STUMBL Score and the Thoracic Trauma Severity Score (TTSS) in predicting morbidity and mortality in patients with blunt chest wall trauma, and to evaluate which scoring system provides greater clinical utility for early risk stra…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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Cooking oil swap may tame prediabetes in small trial
Disease control Not yet recruitingThis study will implement a four-week dietary intervention among middle-aged and older adults with pre-diabetes. Participants assigned to the intervention arm will replace their usual cooking oil with diacylglycerol (DAG) oil, while those in the control arm will consume colza oil…
Sponsor: The First Affiliated Hospital of Guangdong Pharmaceutical University • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Can EQ training help autistic adults and their partners connect better?
Knowledge-focused Recruiting nowSubjects are enrolled in pairs. Pairs consist of an autistic adult age 18-36 and a non-autistic learning partner who has a relationship with the autistic adult, such as a parent. The autistic adult in each pair receives the first stage of Kairon's online leadership training consi…
Sponsor: Kairon Connect, PBC • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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Scientists hunt for clues to tell apart two Look-Alike lymphomas
Knowledge-focused Recruiting nowHodgkin lymphoma (HL) is a lymphoma that arises from peripheral B lymphocytes. However, the neoplastic cells, Hodgkin cells and Reed-Sternberg cells, typically lack most B-cell markers, usually preserving the expression of the transcriptional factor PAX5, only phenotypic clue of …
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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New diabetes drug showdown: which pill protects senior muscle better?
Disease control Not yet recruitingThe goal of this clinical trial is to compare the effects of Henagliflozin Proline Tablets versus Metformin Extended-Release on body composition in elderly, drug-naïve patients with Type 2 Diabetes. The main questions it aims to answer are: The effect of each treatment on the ch…
Phase 4 • Sponsor: Bin Lu • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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New heat therapy could ease stubborn shoulder pain
Symptom relief Not yet recruitingThis study aims to investigate the effect of TECAR therapy on pain, shoulder range of motion, functional disability, and handgrip strength in patients with grade II supraspinatus tendinitis.
Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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Horseback riding may boost muscle strength and sleep quality, study finds
Knowledge-focused CompletedThis study aims to investigate the effects of regular outdoor horseback riding on lower extremity muscle strength, core stabilization, balance, functional movement capacity, sleep quality, and overall well-being in healthy adults. Participants with at least 6 months of routine ou…
Sponsor: Istinye University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Could a simple solution replace the tourniquet in ankle surgery?
Symptom relief Not yet recruitingThis multicenter, prospective randomized controlled trial investigates the effect of dilute epinephrine irrigation versus tourniquet use on visual field clarity (VFC) during ankle arthroscopy. Patients are randomized into an epinephrine group (normal saline with 1 mL of 1:1000 ep…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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New stapler aims to reduce leaks after colon surgery
Disease control Recruiting nowThe purpose of this study is to evaluate the safety and performance of the Signia™ power handle, Signia™ circular adapter, and Signia™ Tri-Staple™ 2.0 circular reloads (hereafter referred to as Signia™ circular stapler) in patients undergoing left sided colon, sigmoid, or rectal …
Sponsor: Medtronic - MITG • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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New study aims to prevent dangerous blood pressure drops during hip surgery
Symptom relief OngoingFemoral neck fracture surgery in elderly patients is frequently complicated by intraoperative hypotension and inadequate postoperative analgesia. Regional anesthesia techniques are increasingly preferred to reduce hemodynamic instability and improve pain control. This prospective…
Sponsor: Bursa Yuksek Ihtisas Training and Research Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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New pain pump strategy aims to cut opioid use after surgery
Symptom relief Recruiting nowPerioperative pain management affects patient recovery. However, the rate of moderate to severe postoperative pain is as high as 73.8%, which hinders recovery and increases the risk of complications. Although opioids are the first-line analgesics, excessive use leads to adverse r…
Sponsor: Beijing Tiantan Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Brain tumor radiation gets a Same-Day Tune-Up
Knowledge-focused Recruiting nowThe goal of this study is to evaluate the feasibility and effectiveness of same-day radiation planning and treatment. The study will shorten the time interval between radiation planning (radiation mapping) and radiation treatment. The intent of this shorter time interval is to in…
Phase 2 • Sponsor: Ayal A. Aizer, MD • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Teen scoliosis study aims to unlock secrets of spine movement and balance
Knowledge-focused By invitation onlyAdolescent idiopathic scoliosis (AIS) leads to three-dimensional spinal deformity during adolescence, causing deviations in the frontal, sagittal, and axial planes, impairing physical function, balance, and lumbopelvic rhythm. Individuals with AIS exhibit decreased trunk movement…
Sponsor: Hacettepe University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Blood test may predict pain treatment success
Knowledge-focused CompletedThis retrospective observational study aims to evaluate the predictive value of systemic inflammatory markers in determining treatment response in patients with lumbar radicular pain treated with a combination of pulsed radiofrequency (PRF) and transforaminal epidural steroid inj…
Sponsor: Ankara Etlik City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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New obesity pill and shot enter first human tests
Symptom relief Recruiting nowThe goal of this Phase 1 study is to evaluate the safety and tolerability of RT-114 in healthy volunteers. The main objectives are: Primary: To evaluate safety and tolerability of RT-114 when administered as single and multiple doses by assessing treatment emergent adverse event…
Phase 1 • Sponsor: RANI Therapeutics • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC