West Virginia University

This trial tests whether adding a second procedure to a standard weight-loss operation leads to greater weight loss and better metabolic health in adults with obesity. The standard procedure, endoscopic sleeve gastroplasty (ESG), uses stitches to make the stomach smaller. The add…

This study explores whether nicotine replacement therapy (NRT)—using patches and lozenges—can help regular e-cigarette users stop vaping. Participants first vape as usual for three days, then are randomly assigned to either receive NRT for up to seven days or to quit all nicotine…

This study tests two ways of measuring magnesium in the blood to personalize magnesium sulfate (MgSO4) dosing for children after heart surgery. Low magnesium levels can lead to heart rhythm problems and kidney injury. One method measures total magnesium, while the other measures …

This trial tests whether giving IV fluids on a fixed schedule during chemoradiation for head and neck cancer can reduce severe side effects like mouth sores, swallowing problems, and kidney injury. Half of the participants will receive IV fluids twice a week starting in week 3 of…

This early study tests whether a single session of focused ultrasound—using sound waves to gently stimulate a specific brain region—can safely reduce emotional symptoms like agitation, irritability, and anxiety in people with mild dementia. Fifteen participants aged 45 to 80 with…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve symptoms and quality of life for adults with constipation-predominant irritable bowel syndrome (IBS-C). Participants use an ear clip for 30 minutes daily over 60 days. The trial c…

This study looks at whether intermittent fasting is safe and doable for people with advanced solid tumors who are starting immunotherapy. About 90 participants will be split into three groups: no fasting, eating only during an 8-hour window each day, or fasting every other day. R…

This study looks at whether a tai chi program can improve walking and balance in adults with cervical myelopathy, a spinal cord condition. Twenty participants will either take tai chi classes or receive usual care. Their mobility and fall risk will be tracked for a year using sim…

This study looks at whether chewing xylitol gum can reduce pain after getting braces. Sixty teens under 18 will be split into two groups: one chews gum three times a day, the other doesn't. They'll rate their pain and comfort at several points over a week. The goal is to see if t…

This study compares a new FDA-cleared expandable trocar to existing ones used in weight-loss (bariatric) surgery. About 35 adults having sleeve gastrectomy, bypass, or other bariatric procedures will take part. Researchers will check if the new tool slips less and causes fewer co…