Vanderbilt-ingram Cancer Center

This study tests whether analyzing the DNA of a kidney tumor can help doctors pick the most effective treatment for advanced or metastatic clear cell renal cell carcinoma. About 54 adults who have not had prior systemic therapy will receive either a combination of two immunothera…

This study tests a procedure called cryodevitalization, which uses a flexible probe to freeze and kill early-stage lung cancer cells. It is done during a standard biopsy. The goal is to find the safest freezing time and see if the treatment is tolerable for 30 patients with stage…

This study tests a drug called neratinib, which blocks a protein that helps cancer cells grow. It is given before usual treatment to 30 people with stage I-III HER2-mutated lobular breast cancer. The goal is to see if it works better than standard hormone therapy at shrinking tum…

This study tests whether removing as much tumor as possible with surgery before giving a special type of radiation therapy (PRRT) works better for people with advanced neuroendocrine tumors of the stomach, intestines, or pancreas. The radiation drug targets tumor cells and delive…

This early-stage trial tests whether a radioactive imaging agent called 111In-panitumumab can help find cancer that has spread to lymph nodes in people with head and neck cancer. About 30 patients scheduled for surgery will receive the agent and undergo SPECT/CT scans. The goal i…

This early-phase study tests a radioactive tracer called [68Ga]Ga-ABY-025 for PET scans in 30 adults with advanced HER2-positive cancers (breast, stomach, head/neck, esophageal). Participants receive the tracer and a PET/CT scan while on standard HER2-targeted therapy. The main g…

This early-phase trial is testing whether combining two imaging techniques can help surgeons find and remove head and neck cancer more completely. About 40 adults with head and neck cancer will receive a special radioactive dye before surgery, followed by a fluorescent dye during…

This early-phase study tests a new radioactive tracer called [18F]NOTA-ABY030, which is designed to make head and neck squamous cell carcinoma show up more clearly on PET/CT scans. About 25 adults with suspicious or unclear findings on standard scans will receive the tracer and b…

This study follows 900 retinoblastoma survivors and their families over time to learn about long-term health outcomes. Researchers collect vision tests, tissue and saliva samples, and questionnaires to understand what causes the cancer, how treatments affect health later in life,…

This early-phase trial is testing a fluorescent dye attached to the cancer drug panitumumab to help surgeons see head and neck cancer tissue during surgery. 18 adults with head and neck squamous cell carcinoma will receive the dye before their planned surgery. The goal is to find…

This study is following 2,100 people of all ages who have had sarcoma, a rare type of cancer. Researchers want to learn how the disease and its treatments affect survivors over time, including side effects, lifestyle, and overall well-being. Participants will fill out surveys, pr…

This study collects and stores tissue and blood samples from 3,000 melanoma patients to identify biological changes linked to the start and spread of the disease. The goal is to help doctors and patients make more informed treatment decisions based on each tumor's unique molecula…

This study compares two ways of taking tissue samples from lung cancer tumors to see which method gives better material for genetic testing. About 250 adults with suspected lung cancer will be randomly assigned to get either a standard needle biopsy or a newer freezing biopsy. Th…

This study collects blood, urine, sputum, and lung tissue from 4,000 adults at high risk for lung cancer. Researchers analyze these samples to find DNA changes and other markers that could signal cancer early. The goal is to better understand how lung cancer develops and to find …

This study tests a high-resolution PET-CT scanner that images removed tumors right in the operating room. About 50 adults with solid cancers will get a standard PET tracer before surgery, then the removed tissue is scanned to see if all cancer was taken out. The goal is to see if…

This study collects and analyzes lung tissue from 4,000 people having surgery for early-stage non-small cell lung cancer. Researchers look for unique RNA and protein patterns (fingerprints) in the samples. The goal is to link these fingerprints to how the cancer behaves, such as …

This study is building a registry of 10,000 adults interested in cancer genetics research. Participants fill out a consent form and questionnaires every two years—no treatments or procedures involved. The goal is to gather data for future studies on inherited cancer risks and to …

This study is creating a large collection of tissue, blood, and urine samples from up to 4,000 women with or without breast cancer. The goal is to provide researchers with a valuable resource to study the biology of breast cancer. Participants donate samples during routine care, …