Va Office Of Research And Development

This study tested three different antibiotic regimens for people with recurrent Clostridium difficile infection (C. diff), a serious gut infection that keeps coming back. The goal was to see if newer drugs like fidaxomicin or a tapered/pulsed course of vancomycin work better than…

This study tested a special grape seed extract (leucoselect phytosome) given before surgery to people with early-stage lung cancer. The goal was to see if it was safe and could slow tumor growth. Only 6 people took part, and the study was stopped early, so we don't have clear ans…

This study tested whether a brief 4-session version of cognitive-behavioral therapy (CBT) works as well as the standard 6-session version for treating insomnia in veterans. Insomnia is very common among veterans and can harm daily life and health. The study enrolled 15 veterans w…

This study looked at whether oxytocin, a natural brain chemical that helps with social bonding, could improve social functioning in veterans with schizophrenia. Researchers planned to give oxytocin and use brain scans to see who might benefit. The study was stopped early, so resu…

This study aimed to see if adding Problem Solving Therapy to standard suicide safety planning could reduce suicidal thoughts in older veterans (age 55+) with depression, anxiety, or PTSD. The trial planned to enroll 117 veterans but was terminated early. The approach focused on t…

This study aimed to see if a simple brain-wave test (LDAEP) could predict which veterans with PTSD or depression would improve with the SSRI medication sertraline (Zoloft). Participants took sertraline or a placebo for 14 weeks while researchers measured their brain activity and …

This study tested a smartphone-based program to help veterans with serious mental illness (like PTSD, bipolar disorder, or schizophrenia) better recognize and describe their emotions. The goal was to see if improving emotion awareness could lower suicide risk. Only 11 veterans to…

This early-phase study tested whether breathing mild low-oxygen air (acute intermittent hypoxia) combined with hand exercise training could improve grip and pinch strength in people with chronic cervical spinal cord injury. The study also tested the drug D-cycloserine to see if i…

This study looked at whether a non-invasive magnetic brain stimulation technique called iTMS, combined with hand exercises, could help people with spinal cord injury regain grasping ability. Researchers measured changes in brain signals and hand strength. The trial was terminated…

This study looked at why erythropoietin (EPO), a drug used to treat anemia, can raise blood pressure in people with chronic kidney disease. Researchers planned to enroll 160 participants but stopped early with only 27. The goal was to measure changes in blood pressure and blood v…

This pilot study tested a home-based conservative care program for veterans with advanced chronic kidney disease who chose not to start dialysis. The program involved a team of doctors, nurses, and other specialists providing care at home. Only 2 participants were enrolled before…