Spinal cord injury study tests magnetic pulses to restore grip
NCT ID NCT03447509
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether a non-invasive magnetic brain stimulation technique called iTMS, combined with hand exercises, could help people with spinal cord injury regain grasping ability. Researchers measured changes in brain signals and hand strength. The trial was terminated early, so findings are limited.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- iTMS (magnetic brain stimulation)
- What this could lead to
- If successful, this could point toward a non-invasive therapy to improve hand function after spinal cord injury.
- What could go wrong
- The trial was terminated early, so results are limited. It is a small, early-stage study focused on understanding brain pathways, not a proven treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Mar 2020
- Finished
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Dec 2025
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants who are unimpaired healthy controls: * Male and females between ages 18-85 years * Right handed * Able to complete precision grips with both hands * Able to complete full wrist flexion-extension bilaterally Participants who have had a spinal cord injury: * Male and females between ages 18-85 years * Chronic SCI (\> 1 year post injury) * Spinal Cord injury at C8 or above * Intact or impaired but not absent innervations in dermatomes C6. C7 and C8 during light touch and pin prick stimulus using the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) sensory scores * The ability to produce a visible precision grip force with one hand * Able to perform some small wrist flexion and extension * ASIA A,B,C, or D Exclusion Criteria: Exclusion criteria for enrollment For SCI and Healthy Control Subjects (4-8 exclusion for non-invasive brain stimulation only): * Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease * Any debilitating disease prior to the SCI that caused exercise intolerance * Premorbid, ongoing major depression or psychosis, altered cognitive status * History of head injury or stroke * Pacemaker * Metal plate in skull * History of seizures * Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold * Pregnant females * Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, 60141-3030, United States
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Other studies related to the condition(s) this trial covers.
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