Uppsala University

This study tests whether giving two strong medications one after the other—rituximab then cladribine—is safe and works well for people with relapsing-remitting multiple sclerosis (MS). Sixty adults aged 18 to 50 with active MS within the last year will receive the treatment and b…

This study tests whether extra dental care every three months for three years can prevent or reduce late side effects like dry mouth, cavities, and jaw stiffness in head and neck cancer survivors. 300 adults who completed radiation or chemoradiation will either get this extra sup…

This study tests if a special vacuum dressing (negative pressure wound therapy) can reduce wound problems like infection or reopening after emergency belly surgery. About 720 adults with a large midline incision will be randomly assigned to get either the vacuum dressing or a reg…

This study compares two surgical treatments for thumb base osteoarthritis: total joint replacement with the TOUCH prosthesis and trapeziectomy (removing a bone at the thumb base). Researchers want to see if joint replacement provides better grip strength and fewer complications. …

This large phase 3 trial is testing whether giving immunotherapy for 6 months after surgery for high-risk melanoma is as effective as the standard 12-month course. The study aims to enroll 1,792 adults who have had their melanoma surgically removed. If shorter treatment works, it…

This study looks at people with stage 4 pancreatic neuroendocrine tumors (pan-NET) that have spread. It compares two approaches: having surgery to remove as much tumor as possible (plus optional drug treatment) versus drug treatment alone. The goal is to see which helps people li…

This study tests whether pivmecillinam pills work as well as standard antibiotics for treating febrile urinary tract infections (kidney infections) in adults. Participants who have already improved after 2-4 days of IV antibiotics will take pivmecillinam or continue standard care…

This study compares two treatments for a specific type of broken collarbone (displaced lateral clavicle fracture) in adults. One group gets surgery with a plate and screws, the other uses a simple sling and physiotherapy. The goal is to see if the non-surgical option works just a…

This study tests whether helping people with insomnia sleep better before knee or hip replacement surgery can reduce pain and improve recovery afterward. One hundred adults scheduled for surgery will receive either cognitive behavioral therapy for insomnia or sleep education for …

This study tests two ways to manage pain after open abdominal surgery in children aged 1 to 15. One method uses a nerve block (TAP-block), the other delivers numbing medicine through a small tube placed in the wound. The goal is to see which approach reduces the need for strong p…

This study tests a 10-session group therapy designed to help teens aged 15-18 with autism who also have anxiety or depression. The therapy focuses on changing how they think about their own thoughts. Researchers want to see if the therapy is practical, acceptable, and shows promi…

This study aims to find out if spinal fusion surgery truly helps people with long-term low back pain. Ninety adults with severe, persistent pain will undergo surgery, but half will receive a placebo procedure without fusion. Neither the patients nor their care team will know whic…

This study observes 2000 children aged 0-16 who have noncardiac surgery to see how often kidney injury occurs. Researchers will also test urine markers for early detection. The goal is to find risk factors and improve prevention strategies.

This study tests a Swedish version of a short 8-question shame scale called the External and Internal Shame Scale (EISS). Researchers will ask 350 adults—300 from the public and 50 from a clinic—to fill out the scale and compare it with other questionnaires. The goal is to see if…

This study interviews 30 women who have experienced intimate partner violence and are taking part in a resilience-focused program at Uppsala University Hospital. Researchers want to learn how well the program meets each woman's needs and how it affects their recovery. The goal is…

This study is watching over 7,000 spine surgery patients to see if using a robot to place screws is more accurate and leads to fewer repeat surgeries than the traditional method. Researchers will also track how quickly surgeons learn to use the robot. The goal is to gather real-w…

This observational study aims to find blood markers that show brain injury caused by cancer treatments in children with brain tumors. Researchers will collect plasma samples from 560 children before and after surgery, during radiation or chemotherapy, and up to three years later.…

This study from Uppsala University looks at how a low-fat, fiber-rich diet versus a high-fat, Western-style diet affects sleep quality, heart rate, and metabolism. Twenty-four healthy young adults will follow each diet for about a week, then spend two days in the lab for detailed…

This study looks at whether measuring the water outside cells (extracellular water) can help doctors understand fluid status in sepsis patients with unstable blood pressure. About 20 adults with sepsis in the ICU will have standard care plus extra water measurements. The goal is …

This study is looking at 100 intensive care patients to see if certain inflammatory markers in urine, blood, and sputum can help predict acute kidney injury. The researchers are comparing patients with sepsis, those recovering from major surgery, and non-inflamed individuals. The…

This study is collecting data from 150 patients with a serious heart infection called endocarditis. Researchers will measure antibiotic levels in the blood and use that information to build a computer model. The goal is to find the best dose for each patient, which could help mor…