University Of Oklahoma

This study tests whether people with advanced bladder cancer can safely switch to a single immunotherapy drug (pembrolizumab) after an initial 24-week combination treatment. The goal is to see if this lighter approach can keep the cancer from growing while causing fewer side effe…

This study tests whether giving antibiotics to obese first-time mothers during induced labor can lower their chance of needing a C-section. Obesity raises the risk of complications and C-sections, and a smaller earlier study suggested antibiotics might help. The trial will involv…

This early-phase trial tests whether taking two medications—relugolix and enzalutamide—before and after standard radiation or surgery can improve outcomes for men with high-risk, locally advanced prostate cancer. About 46 participants will receive the drug combination and be moni…

This study tests whether a daily vitamin B3 supplement called Nicotinamide Riboside (NR) can improve brain health and memory in healthy adults aged 60 to 85. Researchers will measure changes in brain blood flow and activity using non-invasive techniques. The goal is to see if NR …

This study tests whether combining the DASH diet with a home walking program helps people with peripheral artery disease (PAD) walk longer and feel better. About 150 adults with leg pain during walking (claudication) will follow the program for 3 months. Researchers will measure …

This study tests whether a remote program that combines mindfulness and physical activity is practical and helpful for people with metastatic breast cancer. The program aims to reduce fatigue, improve mood, and support overall well-being. Researchers will enroll 38 participants t…

This study compares a new digital chest tube drainage system (Thopaz+) to the standard analog system in children who need a chest tube after lung surgery or a collapsed lung. The goal is to see if the digital system reduces how long the tube stays in, how many chest X-rays are ne…

This study looks at how a single dose of propranolol (a beta-blocker) and a nicotine patch, alone or together, change brain activity and cravings when smokers see smoking-related cues. About 80 daily smokers aged 21-60 will have MRI scans and rate their urges. Participants do not…

This study tests a smartphone app called Connect2Care to help African American men learn about prostate cancer and decide whether to get a PSA screening test. About 266 Black men aged 45-69 in Oklahoma who haven't been screened recently will use either the Connect2Care app or a s…

This study is testing a new program to help Native American cancer patients get better coordinated care. It brings together a cancer center and tribal health systems to improve communication and provide culturally sensitive support. About 187 adults newly diagnosed with cancer wi…

This study tests whether high doses of omeprazole, a common heartburn medication, are safe for people with pancreatic cancer who are about to have surgery. Researchers will also look at how the drug affects tumor markers and acidity. About 60 adults with newly diagnosed pancreati…

This study tests whether a gentle electrical pulse to the ear (transcutaneous vagus nerve stimulation) can reduce harmful inflammation and improve heart rate balance in people with septic shock. About 34 participants will receive either active or sham stimulation for 4 hours alon…