The University Of Texas Medical Branch, Galveston

This study tests whether two doses of the HPV vaccine work as well as three doses for women aged 27 to 45. About 618 women will be randomly assigned to receive either two or three shots, and their immune response will be checked over 12 months. If two doses prove effective, it co…

This study looks at whether involving the whole family can help people with type 2 diabetes in rural Kentucky improve their eating and physical activity. Researchers will work with 75 participants and their families to create a 6-month nutrition and exercise plan. The goal is to …

This pilot study tests whether tirzepatide (Zepbound), a drug already used for weight loss, can slow biological aging in adults aged 55 to 70. Ninety participants with a BMI of 27 or higher will either receive weekly injections of tirzepatide or no drug for 24 weeks, followed by …

This study tests whether regular phone calls from a trained peer coach can help older adults (55+) in rural Kentucky better manage their type 2 diabetes. Participants will be assigned to receive weekly or bi-weekly calls to discuss self-care and goals. Researchers will measure ch…

This study compares a minimally invasive procedure called middle meningeal artery embolization (MMAE) to standard open surgery for treating chronic subdural hematoma, a type of brain bleed. About 520 moderately symptomatic adults aged 40-90 will be randomly assigned to one of the…

This study tests whether eating pistachios daily and attending a one-hour healthy habit coaching session can improve sleep in women aged 45-65 with poor sleep quality. Participants will eat either pistachios or potato chips for 30 days and track their sleep. Researchers will meas…

This study looks at whether a 12-week home-based strength training program, supported by technology and telehealth, is practical for 20 adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Participants will start with supervised sessions and gradually exercise on…

This study compares three methods to reduce pain during corticosteroid injections for arthritis, tendinopathy, or nerve compression in the hand, wrist, or elbow: no anesthesia, a vibrating device, or a cooling spray. Each participant will receive two of the three methods to see w…

This study tests a wearable device that uses directional sound to help people with low vision detect obstacles. Fifty participants with normal vision will wear a blindfold and walk a path with obstacles, once with the device and once without. Researchers will measure changes in w…

This study tests whether a combination of famotidine (Pepcid) pills and cromolyn sodium lotion can reduce itching from burn scars. 44 adults with itchy burn scars will take either the active combo or a placebo (plus a standard antihistamine) for 6 months. The main goal is to see …

This study tests whether taking creatine supplements alongside a 12-week virtual exercise program helps breast cancer survivors improve strength, endurance, and body composition more than exercise alone. Sixty women who finished chemotherapy within the last 6 months will particip…

This study tests a new system that combines virtual reality with a walking robot to help people who have had a stroke walk more symmetrically. The robot gives real-time feedback to encourage using the weaker leg more. Thirty people (15 stroke survivors and 15 healthy adults) will…

This study looks at whether sildenafil (the drug in Viagra) can help reduce urine leakage in people with spinal cord injuries. About 24 adults will take either sildenafil or a placebo for 4 weeks and track their bladder leaks in a daily diary. The goal is to see if this common me…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether dry needling—a technique where thin needles are inserted into muscles—can reduce pain and improve quality of life for people with chronic low back pain. Researchers will also check if the approach is practical and acceptable. The study includes 42 adults,…

This study looks at whether a common dietary fiber called inulin can improve fatigue and thinking problems in people recovering from brain injuries. Researchers will give inulin to 130 adults in neurorehabilitation and track changes in their gut bacteria and symptoms. The goal is…

This study tests a new way to treat severe migraines by using a mild electrical current on an artery in the head. Researchers want to see if the procedure is safe and practical for people whose headaches don't get better with standard treatments. About 12 adults with chronic migr…

This study tests whether a telerehabilitation program using technology can help adults aged 18 to 79 recover joint movement and scar quality after a burn. Participants will use a smartphone, tablet, or computer to follow the program from home. The goal is to see if this approach …

This study looks at the gut bacteria of 16 people with advanced solid cancers who are receiving standard immunotherapy. Researchers will analyze stool samples and cognitive function to see if there is a link between the gut microbiome and how well the treatment works. The goal is…

This study looks at why some people lose muscle and strength after weight loss surgery, and why others regain weight. Researchers will track eating habits, grip strength, and body changes in 110 bariatric patients for a year. They will also study genes and metabolism to find fact…

This study looks at how gut bacteria might be linked to memory, thinking, and tiredness in people with cancer. Researchers will collect stool samples and do thinking tests at the start and after 6 months of standard cancer treatment. The goal is to find patterns that could help m…

This study tests a new way to help people who have had a stroke walk more symmetrically. Researchers will use a split-belt treadmill (where each leg moves at a different speed) along with resistance and real-time feedback (like sounds or visuals) to see what combination best impr…

This study looks at how a gentle brain stimulation technique affects the ability to learn leg movements in both healthy adults and people who had a stroke at least six months ago. Researchers will measure changes in stepping speed and brain activity after five sessions combining …

This study compares two muscle relaxant drugs (rocuronium and cisatracurium) used during general anesthesia in people with chronic kidney disease. Researchers want to see which drug leads to fewer lung problems after surgery. About 490 adults with kidney disease will take part.