The University Of Texas Medical Branch, Galveston

This study tests whether two doses of the HPV vaccine work as well as three doses for women aged 27 to 45. About 618 women will be randomly assigned to receive either two or three shots, and their immune response will be checked over 12 months. If two doses prove effective, it co…

This study looks at whether involving the whole family can help people with type 2 diabetes in rural Kentucky improve their eating and physical activity. About 75 participants will work with their families on a 6-month nutrition and exercise plan. Researchers will track blood sug…

This study tests whether tirzepatide, a drug already used for weight loss, can slow biological aging in older adults. 90 people aged 55-70 will receive weekly injections for 24 weeks, followed by 12 weeks off the drug. The focus is on changes in DNA-based aging markers, not weigh…

This study compares a minimally invasive procedure called middle meningeal artery embolization (MMAE) to standard open surgery for treating chronic subdural hematoma, a type of brain bleed. About 520 moderately symptomatic adults aged 40-90 will be randomly assigned to one of the…

This study compares three methods—no anesthesia, vibration, and cooling spray—to see which reduces pain during corticosteroid injections in the hand, wrist, or elbow. About 165 adults with arthritis, tendinopathy, or nerve compression will rate their pain on a 0-10 scale. The goa…

This study is testing a wearable device that uses sound (echolocation) to help people with low vision detect obstacles as they walk. Fifty adults with normal vision will wear a blindfold and walk a path with obstacles, once with the device and once without. The goal is to see if …

This study tests a new system that combines virtual reality with a walking robot to help people who have had a stroke walk more symmetrically. The robot gives real-time feedback to encourage using the weaker leg more. Thirty people (15 stroke survivors and 15 healthy adults) will…

This study looks at whether eating pistachios and attending one health education session can improve sleep in women aged 45-65 who are in late perimenopause or early postmenopause and have poor sleep. Participants will eat a study snack for about a month, meet with a therapist, a…

This study looks at whether sildenafil (the drug in Viagra) can help reduce urine leakage in people with spinal cord injuries. About 24 adults will take either sildenafil or a placebo for 4 weeks and track their bladder leaks in a daily diary. The goal is to see if this common me…

This study tests if delivering lidocaine (a numbing medicine) and steroids directly into an artery in the scalp can safely relieve the intense headaches that follow a type of brain bleed called subarachnoid hemorrhage. The goal is to reduce pain and the need for strong opioid pai…

This study tests whether dry needling—a technique where thin needles are inserted into muscles—can reduce pain and improve quality of life for people with chronic low back pain. Researchers will also check if the approach is practical and acceptable. The study includes 42 adults,…

This study tests whether a combination of three medicines (diphenhydramine, famotidine, and cromolyn sodium) can reduce itching in burn scars. About 44 adults with itchy burn scars will take these drugs and rate their itch level over 6 months. The goal is to find a better way to …

This study looks at whether a common dietary fiber called inulin can improve fatigue and thinking problems in people recovering from brain injuries. Researchers will give inulin to 130 adults in neurorehabilitation and track changes in their gut bacteria and symptoms. The goal is…

This study tests a new way to treat severe migraines by using a mild electrical current on an artery in the head. Researchers want to see if the procedure is safe and practical for people whose headaches don't get better with standard treatments. About 12 adults with chronic migr…

This study is testing whether a 12-week home-based strength training program, supported by video calls, is practical and helpful for adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Researchers will track how many people finish the program and how often they …

This study tests whether a telerehabilitation program using technology can help adults aged 18 to 79 recover joint movement and scar quality after a burn. Participants will use a smartphone, tablet, or computer to follow the program from home. The goal is to see if this approach …

This study looks at whether taking creatine supplements can help breast cancer survivors build strength and endurance more quickly from exercise. Researchers will compare results from 60 women who recently finished chemotherapy to healthy women of the same age. The goal is to imp…

This study looks at how the bacteria in your gut might influence how well immunotherapy works for solid cancers. Researchers will collect stool samples from 16 people with advanced cancer who are already receiving a type of immunotherapy called PD-1/PD-L1 inhibitors. The goal is …

This study tests a new way to help people who have had a stroke walk more symmetrically. Researchers will use a split-belt treadmill (each leg moves at a different speed) along with resistance and real-time feedback (like sounds or visuals) to see what combination best improves l…

This study looks at how gut bacteria (the microbiome) are linked to thinking problems and fatigue in people with cancer. Researchers will collect stool samples and test memory and attention in 250 adults undergoing standard cancer treatment. The goal is to better understand these…

This study looks at why some people lose muscle and strength after weight loss surgery, and why others regain weight. Researchers will track eating habits, grip strength, and body changes in 110 bariatric patients for a year. They will also study genes and metabolism to find fact…

This study looks at how a gentle brain stimulation technique affects the ability to learn leg movements in both healthy adults and people who had a stroke at least six months ago. Researchers will measure changes in stepping speed and brain activity after five sessions combining …

This study compares two muscle relaxant drugs (rocuronium and cisatracurium) used during general anesthesia in people with chronic kidney disease. Researchers want to see which drug leads to fewer lung problems after surgery. About 490 adults with kidney disease will take part.