New hope for brain bleed patients: could a simple embolization replace surgery?

NCT ID NCT06347796

Recruiting now Disease control Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a minimally invasive procedure called middle meningeal artery embolization (MMAE) to standard open surgery for treating chronic subdural hematoma, a type of brain bleed. About 520 moderately symptomatic adults aged 40-90 will be randomly assigned to one of the two treatments. The main goal is to see if MMAE reduces the need for additional rescue surgery or death, while also checking its safety.

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Conditions

The condition(s) this trial relates to.

Hematoma, Subdural, Chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC SUBDURAL HEMATOMA

Contacts and locations

Locations

Baptist Medical Center Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Cooper University Hospital
RECRUITING

Camden, New Jersey, 08103, United States
Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Good Samaritan Hospital
RECRUITING

Cincinnati, Ohio, 45220, United States
Ichan School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
JFK Neuroscience Institute, JFK University Medical Center
RECRUITING

Edison, New Jersey, 08820, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mercy Health St. Vincent Medical Center
NOT_YET_RECRUITING

Toledo, Ohio, 43608, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Philadelphia Neurological Institute
RECRUITING

Upland, Pennsylvania, 19013, United States
Rutgers, The State University of New Jersey
RECRUITING

Newark, New Jersey, 07101, United States
SUNY Upstate Medical University
ACTIVE_NOT_RECRUITING

Syracuse, New York, 13210, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 61660, United States
University of Miami Miller School of Medicine
RECRUITING

Miami, Florida, 33136, United States
University of Minnesota
WITHDRAWN

Minneapolis, Minnesota, 55455, United States
University of Missouri Healthcare
RECRUITING

Columbia, Missouri, 65212, United States
University of Pennyslvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of South Florida
RECRUITING

Tampa, Florida, 33617, United States
University of Texas Health Science Center-Houston
RECRUITING

Houston, Texas, 77030, United States
University of Texas Health Science Center-San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Texas Medical Branch
RECRUITING

Galveston, Texas, 77555, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Washington
RECRUITING

Seattle, Washington, 98104, United States
Wake Forest University
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Washington University, St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
Westchester Medical Center
RECRUITING

Valhalla, New York, 10595, United States

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