Shanghai Jiao Tong University School Of Medicine

This study tests giving chemotherapy before surgery to men with high-risk prostate cancer. The goal is to see if this approach helps keep the cancer from coming back or spreading for at least 5 years. About 300 men aged 40 to 75 with no prior chemo will take part. The treatment a…

This study tests a new treatment called CS-121 for children aged 4 to 18 with a rare condition that causes extremely high levels of fat in the blood (hyperchylomicronemia). The treatment uses gene editing to target a protein that controls fat levels. The main goals are to see if …

This study tests a new combination of drugs given before surgery for people with HER2-positive breast cancer. About 50 participants will receive the drugs to see if the tumor shrinks enough to avoid more chemotherapy. If the tumor does not shrink enough, patients will switch to a…

This study tests two different drug combinations given before surgery for early or locally advanced HER2-positive breast cancer. The goal is to see which combination clears cancer DNA from the blood faster, which may predict better outcomes. About 60 participants will be randomly…

This study tests a new, faster version of magnetic seizure therapy (MST) for people with psychotic disorders like schizophrenia. The goal is to see if adding MST to standard antipsychotic medication can improve symptoms and thinking. Fifty adults aged 18-55 will receive the treat…

This study tests two drugs, Sac-TMT and KL-A167, given before surgery to people with early-stage triple-negative breast cancer. The goal is to see if the combination can eliminate or shrink the tumor enough to improve long-term outcomes. About 40 participants will receive the tre…

This early study tests a personalized mRNA vaccine (mRNA-0523-L001) in 21 adults with advanced endocrine tumors, such as adrenal, thyroid, or pancreatic cancers, that have not responded to standard treatments. The vaccine is designed to train the immune system to attack each pati…

This study compares a reduced dose (35mg/kg) versus the standard dose (50mg/kg) of a drug called cyclophosphamide, given after a stem cell transplant to prevent graft-versus-host disease (GVHD). About 316 people receiving a transplant from a matched unrelated or half-matched dono…

This study tests a reduced-intensity chemotherapy combination (fludarabine, busulfan, and melphalan) given before a stem cell transplant in people aged 55 and older with certain blood cancers (AML, MDS, CMML). The goal is to see if this gentler approach can help patients stay fre…

This study tests whether Shenling Baishu Granule, a traditional Chinese medicine, can prevent low-risk colorectal adenomas (precancerous polyps) from returning after removal. About 624 adults who recently had polyps removed will take the granule or no treatment for up to 3 years.…

This study tests a new system for teenagers with scoliosis who need to wear a back brace for many hours each day. The system uses small sensors in the brace, a home device with fun progress feedback, and a mobile app to track wear time and motivation. The goal is to see if this a…

This study will follow 600 adults aged 18 to 75 with adrenal diseases like Cushing's syndrome or adrenal tumors. Researchers aim to improve diagnosis, understand disease patterns, and find better treatments. Participants may have had surgery, radiation, or medication before joini…

This study aims to create a standardized quality assessment system for confocal enteroscopy, a technique that allows doctors to see cells in real time during a small bowel exam. Researchers will enroll 600 participants to measure how often the procedure is successful and how accu…

This study looks for early signs of heart trouble in children with lupus using safe, non-invasive ultrasound scans. Researchers will measure heart size, pumping strength, and valve function in 60 participants. The goal is to find better ways to detect heart problems early, not to…

This study looks at whether taking proton pump inhibitors (PPIs), common acid-reducing drugs, changes the accuracy of a stool DNA test for H. pylori infection. Researchers will test 25 adults who need long-term PPI therapy, comparing stool DNA test results while on PPIs and after…

This study looks at 8,000 obese young adults in eastern China to find out how genes and body traits are linked to obesity and metabolic syndrome. Participants must have a BMI of 30 or higher and be willing to give a blood sample. The goal is to learn more about what causes obesit…

This study tests whether a special light during colonoscopy helps doctors find more precancerous polyps than the standard light. About 800 adults aged 45 to 85 getting a colonoscopy will take part. The goal is to see if the enhanced light improves detection without changing the p…