Herbal granules aim to stop colon polyps from coming back
NCT ID NCT06930157
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether Shenling Baizhu granules, a traditional Chinese medicine, can prevent low-risk colorectal adenomas from recurring after they are removed during a colonoscopy. About 624 adults aged 18-70 will take the granules three times daily for six months or receive no additional treatment. Researchers will check for new polyps within three years to see if the granules help reduce recurrence.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Shenling Baizhu granules (traditional Chinese medicine)
- What this could lead to
- If it works, this could provide a natural option to reduce the chance of colorectal polyps coming back after removal.
- What could go wrong
- This is a phase 4 trial, but it's still early for this specific use. The results may not apply to everyone, and the granules may not work better than no treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
About 624 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Nov 2025
- Expected to finish
-
Dec 2028
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Meets the diagnostic criteria for low-risk colorectal adenoma. * Has undergone a colonoscopy of adequate quality (adequate bowel preparation, cecal intubation achieved, and withdrawal time ≥6 minutes) and received endoscopic minimally invasive polypectomy. * Within 3 months after adenoma resection. * 18-70 years of age; any sex. * Willing to participate and has voluntarily provided written informed consent. Exclusion Criteria: * Incomplete adenoma resection. * Long-term use of aspirin, folic acid, calcium supplements, vitamin D, or similar agents. * Known hereditary polyposis syndromes (e.g., familial adenomatous polyposis) or hereditary colorectal cancer syndromes (e.g., Lynch syndrome/hereditary nonpolyposis colorectal cancer). * Colonoscopy findings strongly suggestive of inflammatory bowel disease. * History of malignancy within the past 5 years. * Pregnant or breastfeeding women, or participants with pregnancy potential who are planning pregnancy. * Severe cardiovascular or cerebrovascular disease, hepatic or renal insufficiency, or diabetes mellitus. * Severe psychiatric disorders that would preclude cooperation with colonoscopy procedures. * Current condition preventing oral administration of the study drug (e.g., dysphagia, chronic diarrhea, intestinal obstruction). * Participation in another clinical study within the past 3 months or current participation in another clinical study. * Any other condition that, in the investigator's judgment, makes the participant unsuitable for enrollment.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Low-risk colorectal adenoma are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Renji Hospital
RECRUITINGShanghai, Shanghai Municipality, China