Shanghai Chest Hospital

This study tests whether adding targeted radiation (SBRT) to immunotherapy (toripalimab) and chemotherapy before surgery can improve outcomes for people with stage II-III non-small cell lung cancer. About 478 participants will be randomly assigned to receive either the triple com…

This study is for people with advanced non-small cell lung cancer whose cancer has started to grow again after initial immunotherapy. It tests a combination of toripalimab (an immunotherapy drug) and cryoablation (a treatment that freezes and destroys tumors). The goal is to see …

This study follows 100 people with stage IIB-III non-small cell lung cancer who are getting robotic-assisted sleeve lobectomy after chemoimmunotherapy. Researchers want to see how often the surgery is unsuccessful (needs open surgery, leaves cancer behind, or causes major complic…

This study compares two treatments for small, early-stage lung nodules (ground-glass opacities): cryoablation (freezing the nodule) and thoracoscopic surgery (minimally invasive removal). About 160 adults with nodules 8-20mm will be enrolled. The goal is to see which approach bet…

This study tests a new treatment called InterVapor for people with severe emphysema, a serious lung disease. The treatment uses heated water vapor to target and shrink damaged parts of the lung, making it easier to breathe. The study will compare two different ways of applying th…

This study compares two minimally invasive procedures—transthoracic (through the chest wall) and transbronchial (through the airways)—to destroy early-stage peripheral lung cancer tumors using heat (radiofrequency ablation). About 110 adults with stage IA lung cancer who cannot o…

This early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and helps people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. About 19 adults whose cancer has not respo…

This study tests a new surgical technique called septum-guided segmentectomy for people with early-stage non-small cell lung cancer (tumors 2 cm or smaller) located deep in the lung. The goal is to remove the cancer completely while preserving as much healthy lung as possible, wh…

This study is for people with a specific type of advanced lung cancer (EGFR mutation-positive). After initial treatment with the drug osimertinib plus chemotherapy, doctors will use a simple blood test to look for cancer DNA. If the DNA disappears, patients may be able to stop ch…

This study tests whether adding chemotherapy to the drug surufatinib works better than surufatinib alone for people with a rare type of lung cancer called pulmonary neuroendocrine tumor. About 96 adults will receive either the combination or just surufatinib, and researchers will…

This study tests whether adding low-dose or standard radiation to the usual combination of immunotherapy and chemotherapy can better control metastatic esophageal squamous cell carcinoma. About 100 adults with stage IVB cancer who have not had prior treatment will participate. Th…

This study compares two treatments given before surgery for stage II-IIIA non-small cell lung cancer: immunotherapy (toripalimab) plus radiation versus immunotherapy plus chemotherapy. The goal is to see which combination works better at shrinking tumors and improving surgery out…

This study compares two ways to diagnose small lung nodules: a robot-assisted scope and an ultra-thin scope with computer guidance. About 186 adults with suspicious lung nodules will be randomly assigned to one method. The goal is to see if the robotic approach is at least as goo…

This study tests whether combining electroacupuncture (a type of acupuncture with mild electric pulses) with a standard anti-nausea drug can better prevent nausea and vomiting after lung cancer surgery. About 204 high-risk patients will be enrolled. The main goal is to see if few…

This study is gathering detailed information from 500 people with small cell lung cancer to learn how to personalize their treatment. Researchers will track how well different combinations of radiation and immunotherapy work, and how they affect side effects. The goal is to find …

This study is tracking 200 people with stage IIB-III non-small cell lung cancer to see if shrinking the tumor with chemotherapy and immunotherapy before robotic surgery leads to better outcomes. Researchers will compare surgical results like complete tumor removal and recovery ti…

This study looks at 400 people with non-small cell lung cancer who had pre-treatment (like chemo or immunotherapy) and then needed a specific type of lung surgery called sleeve lobectomy. Researchers want to see if a less invasive surgery (using small cuts and a camera) works as …