Shanghai Chest Hospital

This study tests whether giving two drugs (SHR-A1811 and adebelimumab) before surgery can shrink or eliminate HER2-altered non-small cell lung cancer. About 40 adults with early-stage, resectable cancer will receive the combination, then have surgery to remove any remaining tumor…

This study tests whether adding a nerve-blocking procedure (renal denervation) to a standard heart ablation (pulsed-field ablation) can better prevent early return of atrial fibrillation in 86 adults with persistent AFib. Participants will be followed for 90 days without antiarrh…

This study will test whether a robot-assisted bronchoscope can safely take a tissue sample (biopsy) and then immediately destroy a suspicious lung nodule using heat (radiofrequency ablation) in a single procedure. About 76 adults with small, early-stage lung nodules who cannot or…

This study tests whether dapagliflozin, a drug typically used for diabetes, can help prevent atrial fibrillation from coming back after a heart procedure called catheter ablation. The trial includes 280 adults with persistent AF and increased fat around the heart, but without dia…

This study looks at whether adding an SGLT2 inhibitor (a diabetes drug) to standard cancer treatment can help people with both advanced lung cancer and type 2 diabetes live longer or keep their cancer from growing. About 200 adults will take either the SGLT2 inhibitor or other di…

This study looks at whether a drug called sacubitril/valsartan, which is used for heart failure and high blood pressure, can help people with advanced lung cancer who also have high blood pressure. The goal is to see if it lowers the risk of death and heart problems. About 200 ad…

This study tests whether giving a combination of the immunotherapy drug adebrelimab, chemotherapy, and radiation before surgery can shrink tumors in people with locally advanced thymic carcinoma. About 31 participants will receive 2-4 cycles of this neoadjuvant therapy, then surg…

This study tests a new drug called vebreltinib combined with standard chemotherapy as a first treatment for people with advanced non-small cell lung cancer that has a specific marker (MET overexpression) and no other treatable gene changes. The goal is to see if the combination c…

This study tests a new mobile 4D CT scanner that creates 3D images during a lung biopsy procedure. It involves 50 adults with lung spots needing a biopsy. The goal is to see if this technology provides clearer, more accurate images to help doctors diagnose better.