Shanghai Chest Hospital

This trial is testing a surgical technique called septum-guided segmentectomy for people with early-stage (2-3 cm) non-small cell lung cancer. The surgery aims to remove only the diseased part of the lung, guided by natural anatomical landmarks, while preserving healthy tissue. T…

Researchers are testing whether a doctor can remotely steer a robotic bronchoscope over a 5G network to freeze small lung tumors from inside the airway. The study enrolls about 15 adults with non-small cell lung cancer or controlled metastatic lung tumors, each no larger than 3 c…

This study tests whether a very thin freezing needle can safely biopsy and destroy suspicious lung nodules in one procedure. About 30 adults with small lung nodules who are not candidates for or decline surgery will undergo the combined approach under CT guidance. Researchers wil…

This phase 3 trial compares two surgical approaches for early-stage non-small cell lung cancer with small (≤2 cm), solid-dominant tumors located deep within the lung. One group receives segmentectomy, which removes only the affected segment of the lung, while the other receives l…

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula o…

This clinical trial compares a new three-drug combination (SYHX2011, carboplatin, and enlonstobart) against the standard three-drug regimen (nab-paclitaxel, carboplatin, and tislelizumab) as a first treatment for people with advanced squamous non-small cell lung cancer. The study…

This phase 2 trial tests a new drug called vebreltinib combined with standard chemotherapy as a first treatment for people with advanced non-small cell lung cancer that has MET overexpression and no other known genetic drivers. The study will enroll 19 participants to see if the …

This study will test whether a robot-assisted bronchoscope can safely take a tissue sample (biopsy) and then immediately destroy a suspicious lung nodule using heat (radiofrequency ablation) in a single procedure. About 76 adults with small, early-stage lung nodules who cannot or…

This phase II trial tests whether combining the immunotherapy drug adebrelimab with chemotherapy and radiation before surgery can help shrink tumors in people with locally advanced thymic carcinoma. About 31 participants will receive the treatment, then have surgery if the tumor …

This trial tests whether dapagliflozin, a drug typically used for diabetes, can reduce the return of atrial fibrillation after a heart ablation procedure. The study focuses on patients with persistent AF and increased epicardial adipose tissue (heart fat), which is linked to high…

This study tests two drugs (SHR-A1811 and adebelimumab) given before surgery to people with early-stage non-small cell lung cancer that has a specific genetic change (HER2 alteration). The goal is to see if the combination can shrink or eliminate the tumor before it is removed. A…

This study looks at whether adding an SGLT2 inhibitor (a type of diabetes pill) to standard cancer treatment can help people with advanced lung cancer and diabetes live longer or slow their tumor growth. About 200 adults will take either the SGLT2 inhibitor or other diabetes drug…

This study looks at whether a drug called sacubitril/valsartan, already used for heart failure and high blood pressure, can help people with advanced lung cancer who also have high blood pressure. The goal is to see if it reduces the risk of death and heart problems. About 200 ad…

This study tests a new self-driving robotic bronchoscope that automatically navigates the airways to reach and sample lung nodules. Thirty adults with suspicious lung nodules will undergo the procedure under general anesthesia. The goal is to see if the robot can safely and accur…

This study will test a new mobile 4D CBCT scanner that creates 3D images of lung lesions during a biopsy procedure. Researchers want to see if the images are clear and accurate enough to help doctors diagnose peripheral lung lesions. Fifty adults with small to medium-sized lung s…

Researchers are testing whether giving an anti-PD-1 immunotherapy drug together with anlotinib after surgery can prevent or delay the return of esophageal squamous cell carcinoma. The trial enrolls adults aged 18 to 75 who had chemotherapy plus immunotherapy before surgery, then …