Royal Marsden Nhs Foundation Trust

This early-phase study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple-negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants with advance…

This study is for men with intermediate-risk prostate cancer who need radiation therapy. It compares the usual radiation dose to a lower dose, both given in just two sessions using a special MRI-guided machine. The main goal is to see if the lower dose causes fewer urinary side e…

This study looks at how well people do after a second surgery (salvage surgery) for head and neck cancer that has come back or remained after initial treatment. Researchers will track survival and quality of life in 400 adults. They will also study tumor genetics to understand wh…

This study looks at why head and neck cancer sometimes comes back after radiation treatment. Researchers will collect tissue and blood samples from 20 people who need robotic surgery for their cancer. By comparing the original tumor with the one that returned, they hope to learn …

This study is collecting tissue and blood samples from 500 people with breast cancer who are receiving treatment before surgery. Researchers will analyze these samples to learn why some cancers respond well to therapy while others do not. The goal is to find better ways to predic…

This study follows 200 adults with solid tumors who are starting immunotherapy (checkpoint inhibitors). Researchers collect blood and tissue samples before and during treatment to understand why some patients develop immune-related side effects. The goal is to find early warning …