Royal Marsden Nhs Foundation Trust

This study tests whether adding the experimental drug ipatasertib to standard hormone therapy and a targeted drug can help people with a certain type of advanced breast cancer (ER+/HER2-). The trial includes 57 participants whose cancer did not respond well to initial treatment. …

This early-stage trial tests a combination of two drugs (guadecitabine and pembrolizumab) in about 60 people with advanced solid tumours, including non-small cell lung cancer, that no longer respond to standard treatments. The main goal is to find the safest dose and check for si…

This study follows 170 men with metastatic hormone-sensitive prostate cancer who choose to take apalutamide as part of their normal treatment. Researchers will track PSA levels and use questionnaires to measure fatigue, thinking skills, and quality of life over two years. The goa…

This study looks at whether melanoma patients who had immunotherapy (immune checkpoint inhibitors) may have heart problems years later. Researchers will invite 60 people who finished treatment 2 to 10+ years ago to have heart tests. The goal is to see if this kind of long-term mo…

This study looks at a new surgical technique called tongue base mucosectomy (TBM) to find the original cancer site in patients with head and neck cancer that has spread to lymph nodes but has no known starting point. About 100 patients will have their tongue base tissue removed a…