Northwestern University

This study is for people with liver cancer that cannot be removed by surgery. Researchers want to find the exact amount of radiation needed to completely destroy tumors using a treatment called Yttrium-90 radioembolization. About 30 adults will take part to help improve how this …

This study tests whether adding the drug Anakinra to the fluid that donor lungs are stored in can prevent a serious complication called primary graft dysfunction after lung transplant. About 20 adults getting a lung transplant will take part. The drug aims to reduce inflammation …

This early-stage study tests whether anti-estrogen medications can safely shrink inguinal (groin) hernias in men aged 50 and older. About 75 participants will receive one of two doses of fulvestrant (injection) or letrozole (pill) for 6 months. The main goal is to check safety, b…

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. The goal is to see if this approach better protects a woman's egg supply (ovarian reserve) compared to the standard surgery that removes the entir…

This study tests a new drug (BMS-986504) combined with pemetrexed in people whose cancers have spread and lack the MTAP gene. The goal is to see if the combination is safe and can shrink or control tumors. About 72 adults with certain metastatic cancers (like pancreatic, colon, o…

This study tests a low-dose cancer drug, erlotinib, to treat rare genetic skin conditions that cause thick, scaly, and painful skin. About 44 adults with confirmed diagnoses will take the drug for 24 weeks. The goal is to see if it safely reduces skin thickening and pain, and to …

This early-phase trial tests a new drug called futibatinib combined with two standard cancer treatments (paclitaxel and ramucirumab) for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery. The main goal is to find the s…

This study tests a technology-based program to help women with high blood pressure get their numbers under control before pregnancy. About 350 women aged 18-44 who get care at community health centers will use remote blood pressure monitoring and medication support. The goal is t…

This study tests whether giving a lower dose of radiation to the neck lymph nodes (not directly involved with the cancer) can reduce side effects while still curing HPV-related throat cancer. About 100 adults with early-stage HPV-positive throat cancer will receive this lower-dos…

This study tests a computer tool that helps emergency doctors notice fatty liver on scans, tell patients, and recommend next steps. About 4,700 adults with fatty liver found on an ER scan will take part. The goal is to improve diagnosis and follow-up care for this often-overlooke…

This study is testing a program called Mothers and Babies adapted for parents of infants with Down syndrome (MBDS). The goal is to prevent depression by helping parents cope with grief and build social support. About 72 expectant and new parents (including fathers and nonbinary p…

This study looks at whether smartphone apps can help people who have had melanoma avoid too much sun. About 150 participants will wear a UV sensor and activity tracker, answer daily surveys, and try up to five different app-based sun protection programs. The goal is to see which …

This study tests a program called S.A.F.E. Firearm in up to 15 Illinois health centers. Doctors will talk with parents about safely storing firearms and offer free cable locks during well-child visits. The goal is to see if this program helps parents lock up guns and if clinics c…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. The program starts with resistance training (like lifting weights) to build muscle, then adds aerobic exercis…

This study aims to improve mobility and satisfaction for veterans with lower limb loss by using a personalized approach. Participants will try different prosthetic foot styles to find their favorite, then receive either standard care or a tailored physical therapy program for eig…

This study is testing whether a text-message program can help young adults (ages 18-24) who have suicidal thoughts create and use a personalized safety plan. The program sends interactive texts to help users identify warning signs, coping strategies, and support resources. The go…

This study tests a new training method called MINT that uses muscle signals to control a computer interface, aiming to improve walking after a stroke. About 72 adults who had a stroke at least 6 months ago and have trouble walking will participate. The goal is to see if this appr…

This study tests two treatments for pain after amputation. For people with leg amputations, doctors will inject alcohol near painful nerve endings (neuromas) to block pain signals. For those with arm amputations, a high-dose capsaicin injection will be used instead, to avoid harm…

This study tests whether adding an injection of Xeomin (a Botox-like drug) into the penis can improve erections in men with mild-to-moderate erectile dysfunction who already take tadalafil (Cialis). About 30 men will receive both the injection and a placebo injection at different…

This study tests whether a chair called Emsella can reduce short-term stress urinary incontinence (leaking urine when coughing or sneezing) that sometimes happens after prostate surgery for an enlarged prostate. About 30 men with enlarged prostates will receive Emsella treatments…

This study tests whether a special vibration tool can improve pain control after surgery for a broken wrist (distal radius fracture). About 100 adults who have had this surgery will use the device and report their pain levels and how many pain pills they take. The goal is to see …

This study tests whether a shorter muscle cut in the esophagus works as well as the standard longer cut for people with swallowing problems due to achalasia. About 372 adults will be randomly assigned to receive either the shorter or standard procedure, and their symptoms will be…

This study tests a smartphone app designed to help teenagers aged 14 to 18 who hurt themselves on purpose and are not currently in therapy. The app provides support and information to help them cope with difficult feelings. The goal is to see if the app is easy to use and helpful…

This study tests a special band-aid (called the A-Band) and a smartwatch that use AI to measure pain in women with chronic pain. About 115 women will wear the patch on their arm for up to 90 minutes at a time over a week, while also wearing a smartwatch and answering pain questio…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This study follows 285 older adults (65+) with Alzheimer's or mild cognitive impairment, along with their caregivers, to understand how they make decisions about staying at home or moving to long-term care. Researchers will track planning over time, looking at factors like thinki…