Northwestern University

This study is testing a drug called Ublituximab (Briumvi) in 40 adults with early relapsing multiple sclerosis (MS). The goal is to see if giving the drug twice a year is safe and can reduce signs of nerve damage in the blood. Participants will receive the treatment and be monito…

This study tests a drug called cemiplimab in 15 people with a rare and incurable cancer called NUT carcinoma. The drug helps the immune system attack cancer cells. The goal is to see if it can shrink tumors or help people live longer.

This study looks at whether adding a GLP-1 agonist (a type of diabetes drug) to the MS medication ocrelizumab can reduce disability progression in people with multiple sclerosis. Researchers will track 100 adults with MS over 72 weeks, measuring changes in walking, hand function,…

This study is testing whether giving fresh frozen plasma (FFP) along with standard care is safe and helps people recover from moderate to severe traumatic brain injury. About 357 adults aged 18 to 65 will be randomly assigned to receive either standard care alone or standard care…

This study tests a radiation treatment (Y90) to help the liver grow enough for people with liver cancer to have surgery to remove tumors. About 104 participants will receive Y90, and researchers will find the best dose to maximize liver growth. The goal is to make more patients e…

This study tests a program that combines peer support and text messages to help young men and transgender women (ages 15-29) living with HIV in Nigeria stick to their treatment and lower their virus levels. Participants will receive guidance from a peer navigator and health tips …

This study tests whether adding PET-guided radiation to standard hormone therapy can better control metastatic prostate cancer. About 125 men with hormone-sensitive prostate cancer that has spread will be randomly assigned to receive standard treatment alone or with targeted radi…

This study aims to help control high blood pressure in Chicago's South Side, where rates are high and resources are low. About 2,000 adults from local churches and clinics will take part in a program led by community health workers. The program uses proven methods like simplified…

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started Parkinson's medication will be assigned to either moderate or high-intensity treadmill wor…

This study tests if breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with moderate to severe ulcerative colitis flares. The goal is to see if this treatment can improve symptoms and reduce the need for stronger medications or…

This study is testing an online program called My Wellbeing Guide to help cancer patients feel less depressed and anxious. About 6,500 adults with cancer and high depression symptoms will use the app for 7 weeks, watching videos and doing activities. The goal is to see if the app…

This study tests whether a single spinal injection of morphine before lung surgery can reduce pain and the need for other painkillers afterward. About 90 adults having video-assisted or robotic lung surgery will be randomly assigned to receive either the morphine shot or a placeb…

This study looks at whether dupilumab, a medication for moderate to severe eczema, can improve sleep and reduce itching in children aged 6 to 17. Over 12 weeks, researchers will measure sleep quality and itchiness before and after treatment. The goal is to see if the drug helps r…

This study tests whether shining a special red light on the legs each day before a walking workout can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to poor blood flow. The trial involves 32 adults aged 50 and older …

This study looks at whether having a physical therapist in the emergency department (ED) helps people with low back pain get better care sooner. About 140 adults with recent low back pain will take part at two hospitals. The goal is to see if this approach is practical and can re…

This study tests if a special sound wave therapy (called shockwave therapy) can reduce hard, scar-like tissue that sometimes forms after breast surgery. About 100 adults who had plastic surgery and now have firm tissue will get this treatment. Researchers will measure if the scar…

This study looks at two different ways to place a new knee joint during replacement surgery. The traditional method aims for a neutral position, while the newer method tries to match each person's natural knee alignment. Researchers want to see which approach leads to better pain…

This study is testing two different parent-led therapies for young children with autism, ages 18 to 48 months. The goal is to find the best order to give these therapies to improve the child's social communication and reduce disruptive behaviors. Researchers will also look at wha…

This study looks at whether over-the-counter hearing aids can improve communication for people over 60 with mild hearing loss and mild cognitive impairment or early Alzheimer's. Participants and a partner will try either hearing aids first or communication tips first. The goal is…

This study tests a mobile phone program that sends timely reminders to help teenagers and young adults (ages 14-29) with acute lymphoblastic leukemia take their oral chemotherapy pills as prescribed. The program is designed to adapt to each person's needs in real time. The main g…

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex but never been tested will receive either helpful texts or general health information. Researchers will then check if more teens in the text grou…

This study looks at how the brain changes after a stroke and how those changes affect arm and hand movement. Researchers will use brain scans and movement tests to find early signs that predict recovery. The goal is to better understand why some people develop movement problems a…

This study collects blood, skin, and spinal fluid samples along with health information from 2,500 adults with neuromuscular diseases like ALS, neuropathy, and muscular dystrophy. The goal is to create a large, shared database that researchers can use to better understand these c…

This study compares three different ways of delivering speech therapy to toddlers with developmental delays. About 1,269 children will receive either therapist-led sessions, caregiver coaching, or a combination of both. The goal is to find which approach best helps children commu…

This study looks at how uneven brain shrinkage affects language skills in people with primary progressive aphasia (PPA). Researchers will use MRI scans and language tests to track changes over time. The goal is to better understand the disease, not to test a treatment. Participan…

This study tests whether a digital cognitive test can help primary care doctors detect early memory problems and dementia in underserved communities. About 45,000 adults aged 65 and older without prior diagnosis will participate across 24 clinics. The goal is to improve early det…