National Institute On Drug Abuse (nida)

This study tests whether semaglutide, a drug used for diabetes, can help people with alcohol use disorder drink less. About 80 adults will receive either the drug or a placebo shot weekly for 5 months. Researchers will measure changes in drinking, brain activity, and cravings usi…

This study tests whether a combination of two medications, extended-release naltrexone and bupropion, can help people with moderate to severe methamphetamine use disorder reduce their drug use. About 360 adults who want to cut back or quit will receive either the medication or a …

This study tests spironolactone, a blood pressure medicine, in 20 adults with alcohol use disorder to see how the body processes it and if it changes the effects of alcohol. Participants stay at a clinic for four week-long visits, taking the drug or a placebo, and then drink alco…

This study screens up to 10,000 people aged 18 and older, with or without substance or alcohol use disorders, to see if they qualify for other NIDA research studies. Participants undergo a single screening visit that may include physical exams, blood tests, memory tests, and ment…

This study looks at how different activities and settings influence drinking behaviors and mental health in people with alcohol use disorder. About 44 adults will try virtual reality, games, or videos, then answer questions about cravings and alcohol use. The goal is to understan…

This study aims to build a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants use an app that tracks phone activity and location, and answer questions about mood and substance use. The goal is to underst…

This study looks at how nicotine changes brain activity in people with major depressive disorder compared to those without. Researchers will use MRI scans and tasks to measure brain function after giving participants either nicotine or a placebo. The goal is to understand why peo…

This study aims to create and validate computer tasks that measure how people learn and make decisions. Researchers will use these tasks in future studies on substance use disorders. Healthy adults aged 18-45 from the Baltimore area can join. Participants will complete tasks invo…

This study tests whether suvorexant, a drug approved for insomnia, can reduce cravings and brain responses linked to smoking in daily smokers and vapers aged 18-60. Researchers will use brain scans and sleep tracking to see how the drug works over a few weeks. A separate group of…

This study aims to understand how people with opioid-use disorder learn and make decisions compared to those without the disorder. Participants will complete a computer task where shapes are paired with food odors, and their responses and breathing will be monitored. The goal is …

This study tests how a non-invasive brain stimulation technique called TMS affects learning and decision-making in healthy adults aged 18 to 45. Participants will undergo TMS sessions and brain scans while performing computer tasks. The goal is to understand normal brain function…

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. TMS uses magnetic pulses to stimulate the brain and is already approved for depression. Researchers want to understand these effects better to design treatments for drug addi…

This study aims to develop better MRI techniques to see how drug addiction changes the brain. Researchers will scan the brains of up to 1,000 adults, including smokers, non-smokers, and people who use drugs or not. The goal is to improve our understanding of addiction and pave th…