National Institute On Drug Abuse (nida)

This study tests a medicine called tirzepatide to see if it can help people with moderate to severe cannabis use disorder use less cannabis or stop altogether. One hundred adults aged 18 to 70 will receive either the drug or a placebo, and researchers will track their cannabis us…

This early-stage study tests a new oral medication called VK4-116 in 48 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for opioid dependence and opioid use disorder. Participants will receive a single dose o…

This study uses a gentle ultrasound technique to temporarily change activity in brain areas linked to smell. Researchers want to understand how odors influence our actions. Eighty healthy adults aged 18-45 will do computer tasks while smelling different scents, with brain scans a…

This early-stage study tests a new form of transcranial magnetic stimulation (TMS) called high-density theta burst stimulation (hdTBS) in 35 healthy adults aged 22 to 60. The goal is to check if hdTBS is safe and to compare its effects on the brain to standard TMS. Participants w…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study is the first time MG001, a formulation of mitragynine from the kratom plant, is being tested in people. Researchers want to see if it is safe and how the body processes it. About 32 healthy adults who have used oral opioids recently will receive a single dose of MG001 …