Murdoch Childrens Research Institute

This study compares two ways to treat bone and joint infections in children aged 1 to 18. One group gets antibiotics only by mouth from the start, while the other gets standard care: a few days of IV antibiotics followed by pills. The goal is to see if the all-oral approach works…

This study looks at a new method for removing breathing tubes from very premature babies (born before 32 weeks). The standard method removes the tube first, then applies a nosepiece for gentler breathing support. The new method, called prePAP, starts the gentler support before re…

This study tests whether using a child's genetic information to guide the dose of the anti-rejection drug tacrolimus can help reach the right drug levels faster and with fewer side effects. About 45 children aged 1-18 who receive a kidney, liver, or heart transplant will take par…

This study tests whether a web app that customizes the dose of the antiviral drug ganciclovir can clear cytomegalovirus (CMV) faster than standard dosing in 232 children with weakened immune systems. Participants are recruited from seven children's hospitals in Australia and New …

This study tests two targeted drugs for people with vascular malformations (abnormal blood or lymph vessels). Participants with slow-flow malformations and a specific gene mutation receive alpelisib, while those with fast-flow malformations and another mutation receive mirdametin…

This study tests whether checking vancomycin levels after the very first dose and adjusting quickly can help infants with sepsis reach the right drug levels faster. About 40 infants under 90 days old will take part. The goal is to avoid dangerous delays in treating serious infect…

This study checks if an artificial intelligence (AI) system can make ultrasound scans more accurate for finding hip dysplasia in babies. About 240 infants will get an extra AI-powered ultrasound during their regular checkup. Researchers will compare the AI results to standard ult…

This study tests whether a special iPad app that generates speech can help children with childhood dementia communicate better. The trial will include 38 children aged 3 to 12. Each child will use the app for 6 weeks and also have a period without it, so the researchers can compa…

This study compares two treatment plans for children with complicated urinary tract infections (UTIs): one group gets a single IV antibiotic dose followed by two days of oral antibiotics, while the other gets three daily IV doses. Both groups finish with a total of 7 days of anti…

This small study tests whether a supervised exercise program can help children and teens (ages 5-17) with acute lymphoblastic leukemia maintain or regain muscle strength during early treatment. Researchers will monitor kids who show signs of weakness after 5 weeks of chemotherapy…

This small pilot study will test whether medicinal cannabis can help ease symptoms like pain and muscle spasms in children receiving palliative care for non-cancer conditions. Ten children aged 6 months to 21 years will receive one of two cannabis products, and researchers will t…

This study looks at whether giving parents of children with chronic conditions a mental health questionnaire during clinic visits can help spot stress, anxiety, or depression. About 100 parents will fill out the survey, get their results and a list of support services, and be che…

This study tests a fertility preservation decision aid for young cancer survivors and their parents. The goal is to see if the tool helps them better understand fertility status, future parenthood goals, and storage fees. About 358 participants will be randomly assigned to receiv…

This study follows children and young people who completed an 18-month oral immunotherapy (OIT) course for peanut, egg, or milk allergy 5 to 15 years ago. Researchers want to see if those who achieved remission have a better quality of life compared to those who did not. Particip…

This study is testing whether wearable devices like smartwatches can help detect infections early in children receiving cancer treatment. About 150 children aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to use this dat…

This study looks at how families decide on antibiotic use for children aged 4-17 with common infections like urinary tract infections, strep throat, and skin infections. Researchers will also test if a Garmin smartwatch and a phone app are easy and acceptable for tracking symptom…

This study looks at how medical oxygen is provided in six countries in Africa and Asia. Researchers will interview policymakers, health workers, and others to find out what works and what doesn't. The goal is to improve oxygen access for people with breathing problems like pneumo…

This study looks at how the bodies of children and young adults (ages 6-25) with Hodgkin or non-Hodgkin lymphoma break down certain drugs. Researchers will give small doses of probe medications during regular hospital visits and take blood samples to measure metabolism. The goal …

This study looks at people who finished venom immunotherapy for Jack Jumper ant allergy 1.5 to 5 years ago. Participants will get a supervised sting and blood test to see if they are still protected. The goal is to learn how long the treatment works and how it affects quality of …