Murdoch Childrens Research Institute

This study tested whether a smaller dose of the Pfizer COVID-19 booster vaccine works as well as the full dose. It involved 601 healthy adults in Mongolia who had previously received two doses of either Sinopharm, AstraZeneca, or Sputnik V vaccines. Researchers compared the immun…

This study tested whether a steroid nasal spray could help children with snoring and sleep-disordered breathing. It involved 130 children aged 3-12 who did not improve after first trying a simple saltwater spray. The main goal was to see if the medicated spray could reduce sympto…

This study aimed to find out if it's as safe to stop antibiotics early for children with cancer who develop a serious fever complication called febrile neutropenia. Researchers compared stopping antibiotics before blood counts fully recovered (early stopping) to the standard prac…

This study tested if a treatment called oral immunotherapy could help toddlers with nut allergies. Children aged 18-36 months who were allergic to two types of nuts were either given tiny, controlled daily doses of nut flour or told to strictly avoid nuts for 18 months. The goal …

This study tested whether giving mothers a single dose of the antibiotic azithromycin during labor could prevent infections in their babies. Over 2,100 mother-baby pairs participated, with half receiving the antibiotic and half receiving a placebo. Researchers tracked the infants…

This study tested if introducing tree nuts early to infants who are already allergic to peanuts can prevent them from developing additional nut allergies. It compared a supervised hospital introduction of four nuts followed by home introduction of others against the standard care…

This study tested whether a medication called methylphenidate (often used for ADHD) could help children with childhood apraxia of speech speak more clearly. Eighteen children aged 6-12 took the drug or a placebo for four weeks each to compare the effects. The main goal was to see…

This study tested whether a purified CBD (cannabidiol) oil could reduce severe behavioral problems in children and teens with intellectual disability. 132 participants aged 6-18 were randomly assigned to receive either CBD or a placebo for 8 weeks. Researchers measured changes in…

This study aimed to safely learn more about how a common strain of strep throat bacteria causes infection. Researchers carefully exposed 40 healthy adult volunteers to the bacteria in a controlled setting to see how much is needed to cause illness and how the body responds. The i…