Murdoch Childrens Research Institute

This study looked at whether a smaller (fractional) dose of the Pfizer-BioNTech COVID-19 booster works as well as the standard dose. It involved 601 healthy adults in Mongolia who had received two doses of Sinopharm, AstraZeneca, or Sputnik vaccines 6 to 9 months earlier. Researc…

This study looked at whether stopping antibiotics early (before white blood cell recovery) is as safe as waiting until recovery in children with cancer who had fever and low white blood cells. 55 children participated. The goal was to see if early stopping leads to more complicat…

This study tested whether a home-based, dietitian-guided egg ladder is safe and practical for infants newly diagnosed with egg allergy. 109 infants followed a step-by-step plan to gradually introduce egg in increasing forms, from baked to raw. The goal was to see if this approach…

This study tested a low-dose oral immunotherapy (OIT) in children aged 18-36 months with allergies to two nuts. One group received daily tiny doses of the nuts they're allergic to, while the other group avoided them completely. After 18 months, researchers checked if more childre…

This study looked at whether giving tree nuts (like almonds, cashews, and walnuts) early to babies with peanut allergy could stop them from developing tree nut allergies. About 212 infants aged 4-11 months with peanut allergy took part. Some babies were given tree nuts under medi…

This study tested whether giving mothers a single 2-gram dose of the antibiotic azithromycin during labour (or just before a C-section) could reduce the number of skin and soft tissue infections in their babies by 3 months of age. Over 2,100 pregnant women took part. The goal was…

This study tested whether a nasal spray containing heparin, a common and safe medicine, can reduce the spread of COVID-19 among people living in the same home. Over 500 adults and children who lived with someone who tested positive for COVID-19 used the spray or a dummy spray thr…

This study tested whether methylphenidate, a drug often used for ADHD, can improve how clearly children with apraxia of speech can speak. 18 children aged 6-12 took either the drug or a placebo, then switched, so each child tried both. The goal was to see if the drug made their s…

This study tested a steroid nasal spray in 130 children aged 3-12 who snore and have sleep-disordered breathing. The goal was to see if the spray could improve symptoms and reduce the need for tonsil or adenoid surgery. Children who did not improve with a saline spray were given …

This study tested whether a purified form of cannabidiol (CBD) can reduce severe behavioral problems in children aged 6 to 18 with intellectual disability. Over 8 weeks, 132 participants received either CBD or a placebo. The goal was to see if CBD could ease symptoms like irritab…

This study tested a new way to study Strep A bacteria, which causes strep throat and can lead to serious illnesses like rheumatic heart disease. Forty healthy adults were carefully exposed to a specific Strep A strain (M1) under controlled conditions to see how much bacteria is n…