Massachusetts Eye And Ear Infirmary

This study tests whether high-dose atorvastatin (a cholesterol-lowering drug) can improve night vision in people with intermediate age-related macular degeneration (AMD). About 21 participants will take the drug and have their dark adaptation (how well eyes adjust to dim light) m…

This study tests whether N-acetyl cysteine (NAC) eye drops can reduce harmful oxidative stress in the eyes of people with Fuchs endothelial corneal dystrophy (FECD). About 45 adults with advanced FECD who are already scheduled for corneal transplant surgery will use the drops for…

This early-stage study tests a special contact lens that slowly releases steroid medicine directly onto the eye. It is for people with recurrent cystoid macular edema, a condition causing swelling in the central retina. The main goals are to see if the lens is safe, comfortable, …

This study tests whether treating donor corneal tissue with a special cross-linking process before transplant can make it stronger and less likely to be rejected. The trial involves 96 adults who need a high-risk cornea transplant due to blood vessel growth in the eye. Researcher…

This study compares three types of glaucoma surgery (Hydrus Microstent, incisional goniotomy, and excisional goniotomy) done at the same time as cataract surgery. About 243 adults with mild to moderate open-angle glaucoma will take part. The goal is to see which surgery lowers ey…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose dystonia, a movement disorder. The goal is to see if the AI can correctly identify dystonia and reduce the time it takes to get a diagnosis. About 1,000 people w…

This study tests whether a medicated eye drop called netarsudil can prevent harmful scar tissue from forming after surgery for a detached retina. About 48 adults who need retinal detachment repair will receive the drops before and after surgery. The main goals are to measure how …

This study looks at whether reducing the number of follow-up appointments after getting a cochlear implant still leads to good hearing and quality of life. Researchers will test a new programming method that may shorten appointment times. The goal is to make follow-up care more e…

This study tests special prism glasses designed to expand the field of view for people with vision loss, such as tunnel vision or hemianopia (blindness in half the visual field). About 20 participants will try different prism designs during several visits to see which works best …

This study tests a small, TENS-like device that gives mild electrical stimulation to see if it can improve balance and walking in older adults. About 120 people aged 60 and older will do tasks like walking for 6 minutes and standing on foam while wearing the device. The goal is t…

This study looks at brain activity and structure in people with different types of focal dystonia (like writer's cramp or spasmodic dysphonia), their unaffected relatives, and healthy volunteers. The goal is to understand what brain changes cause these movement disorders. Partici…

This study is testing a blood test (liquid biopsy) to see if it can find tiny bits of cancer DNA left behind after surgery for a type of skin cancer called cutaneous squamous cell carcinoma. The test may also help doctors monitor how well immunotherapy treatment is working. About…

This study looks at how cochlear implants affect hearing over time and tests new programming methods to improve speech understanding. About 200 children and adults with severe hearing loss who already have a cochlear implant will take part. The goal is to learn how to better adju…

This study uses brain scans like MRI and EEG to find out what makes laryngeal dystonia and voice tremor different in the brain. Researchers will compare brain activity in people with these voice disorders and healthy volunteers. The goal is to better understand these conditions, …

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …

This study aims to better understand and classify different types of voice problems in people with laryngeal dystonia and voice tremor. Researchers will use voice tests and movement analysis to identify distinct symptom patterns. The goal is to improve diagnosis and guide future …