Institut Paoli-calmettes

This study looked at whether reducing the use of strong, broad-spectrum antibiotics in cancer patients with sepsis or septic shock is as safe as continuing them. The goal is to lower the risk of creating drug-resistant bacteria. Researchers compared a de-escalation strategy to st…

This study tested a newer, less invasive surgery called ETAP (done through the anus) against standard laparoscopic surgery (done through the belly) for low rectal cancer. 226 adults took part. The goal was to see if ETAP is as good at removing all cancer while possibly leading to…

This study tested a new type of transplant for people with acute myeloid leukemia or myelodysplastic syndromes who cannot have a standard bone marrow transplant. Instead of using strong drugs to suppress the immune system, doctors gave a small number of stem cells from a partiall…

This study looked at whether taking an oral hormone therapy called apalutamide for 6 months could slow down low-risk prostate cancer and delay the need for more aggressive treatments like surgery or radiation. 93 men on active surveillance (watching the cancer without immediate t…

This early-phase study tested whether giving specially selected donor immune cells (NK cells) soon after a stem cell transplant is safe for people with blood cancers. Seventeen patients received the cells, and researchers monitored for serious side effects within 30 days. The goa…

This study tested a new urine test called VISIOCYT to see how well it finds bladder tumors compared to standard methods. About 700 adults with suspected or follow-up bladder cancer provided urine samples before their regular cystoscopy. The goal was to measure the test's accuracy…

This study aimed to find biological markers (biomarkers) in pancreatic tumor cells and blood that could help predict how well a patient might respond to treatment. Researchers analyzed genetic and protein information from tumor samples collected via ultrasound-guided biopsy, as w…

This study looked at 135 people with advanced lung cancer, lymphoma, or other tumors treated with immunotherapy drugs called checkpoint inhibitors. Researchers collected blood and tumor samples over time to measure immune cells and molecules that might predict whether the treatme…

This study looked at whether analyzing the DNA of tumors from people with advanced or metastatic solid cancers could help doctors pick a targeted treatment. Over 550 patients had their tumor samples genetically tested. The goal was to see how many patients could be matched to a t…

This study looked at 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers collected blood, bone marrow, skin, and cheek samples to study genetic, epigenetic, and immune features. The goal was to find factors that predict how the …