Institut Paoli-calmettes

This study tested a new drug (LY2780301) combined with standard chemotherapy (paclitaxel) in people with advanced HER2-negative breast cancer that had spread or couldn't be removed by surgery. The goal was to find the safest dose and see if the combination could shrink tumors. Th…

This study tested a combination of two oral drugs, BKM120 and lapatinib, in 24 adults with HER2-positive breast cancer that had spread and no longer responded to trastuzumab. The goal was to find the safest dose and see if the combo could shrink tumors. The study was terminated e…

This study tested whether continuously pumping a local anesthetic (ropivacaine) into the surgical wound after mastectomy reduces pain and speeds recovery better than a placebo. The trial involved 59 women with breast cancer and aimed to see if this approach could lower the need f…

This study was designed to track side effects and quality of life in people aged 70 and older with advanced melanoma or non-small cell lung cancer who are starting immunotherapy. Researchers planned to monitor 40 participants for serious side effects and changes in daily well-bei…

This study aimed to find genetic and protein changes in breast cancer that could help predict how the disease behaves. Researchers collected tumor samples from 749 adults with breast cancer and analyzed them for gene activity and mutations. The study was stopped early, so results…