Guy's And St Thomas' Nhs Foundation Trust

This study tests whether adding a special anti-inflammatory mouthwash to a deep-cleaning procedure helps heal advanced gum disease better than the cleaning alone. About 20 adults with severe gum disease will be randomly assigned to use either the active mouthwash or a placebo for…

This study looks at 50 children in intensive care with severe lung infections. It uses a new method to find out which bug is actually making them sick by measuring the body's response in lung fluid. The goal is to give the right antibiotics only to those who need them, reducing s…

This study compares two devices—the Fetal Pillow (an inflatable balloon) and the Tydeman Tube (a manual tool)—used to lift a baby's head when it gets stuck during a full-dilatation C-section. Researchers will measure how quickly the baby is delivered and track complications like …

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study will look at electrical signals and heart images from 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF). Researchers want to understand why AF happens more often and is harder to treat in HCM patients. The goal is to gather information …

This study tests whether a kidney transplant-specific comprehensive geriatric assessment (KT-CGA) can improve how older adults (60+) are evaluated for kidney transplants. Fifty participants will either receive the KT-CGA plus usual care or usual care alone. The goal is to see if …

This study will interview pregnant and postnatal women who have two or more long-term health conditions, as well as their midwives and other healthcare professionals. The goal is to understand their experiences and challenges with midwifery care. The findings will be used to co-d…

This study looks at whether a protein called DKK3 in urine can detect kidney transplant problems earlier than current blood tests. Researchers will collect urine samples from 258 kidney transplant recipients over 12 months and compare the new test with standard measures. If succe…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This study will interview 100 adults from ethnic minority groups, along with community workers and healthcare professionals, to understand why genetic testing services are underused by these communities. The goal is to identify changes that could make genomic medicine more equita…

This study tests a small, smartphone-sized device called Seismofit that measures heart vibrations to estimate fitness in just three minutes. Researchers want to see if it can predict complications like pneumonia and hospital stay length in 164 oesophageal cancer patients undergoi…

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study will interview 15 parents or guardians of children with spinal muscular atrophy type 1 (SMA1) to learn about their daily experiences with feeding and communication. Even though newer medicines have improved survival, how they affect swallowing and speech is still uncle…

This study looks at whether two common anti-clotting drugs, aspirin and clopidogrel, can reduce inflammation in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure how these drugs affect clusters of blood cells called monocyte…