Guy's And St Thomas' Nhs Foundation Trust

This study looks at whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis or thrush. About 114 women will either use lactoferrin vaginal pessaries for 3 weeks or take standard antibiotic/antifu…

This study aims to improve diagnosis of severe lung infections in children in intensive care. It will test whether measuring the body's immune response, along with advanced bug detection, can identify which germ is actually causing the illness. The goal is to give the right antib…

This study tests whether a detailed health assessment designed for older adults (called KT-CGA) can help doctors make better decisions about kidney transplants. About 50 people aged 60 and older with advanced kidney disease will either receive this extra assessment plus usual car…

This study looks at how anxiety and depression influence the way older patients (65+) with critical limb-threatening ischemia make decisions about their treatment. Researchers will interview patients, their caregivers, and healthcare staff to understand the shared decision-making…

This study looks at why people with hypertrophic cardiomyopathy (thickened heart muscle) often develop atrial fibrillation (a type of irregular heartbeat) that is harder to treat. Researchers will study heart electrical signals and imaging in 40 adults with both conditions. The g…

This study looks at whether a protein called Dickkopf 3 (DKK3) in urine can spot kidney transplant problems sooner than current blood tests. Researchers will collect urine samples from 258 kidney transplant recipients over 12 months and compare the new test with standard measures…

This study will compare two tools—the Fetal Pillow and the Tydeman Tube—used to help deliver a baby when the head gets stuck during a C-section at full dilation. About 80 women having a C-section will take part. The goal is to see which device works faster and safer, and to test …

This study will compare two newer types of pacemakers—leadless pacemakers and left bundle branch pacemakers—to see how they affect heart function and the tricuspid valve. Twenty adults with slow heart rhythms will receive both types temporarily during their routine pacemaker impl…

This study will interview 80 pregnant or postnatal women who have two or more long-term health conditions, along with their midwives and other healthcare professionals. The goal is to understand their experiences with midwifery and maternity care, and then work together to create…