Guy's And St Thomas' Nhs Foundation Trust

This study is testing two different procedures—AF catheter ablation and AV node ablation—in 70 people who have heart failure, atrial fibrillation, and a CRT device that isn't pacing enough. The goal is to see which procedure better improves heart function and quality of life afte…

This study tests whether lactoferrin, a natural prebiotic from cow's milk, can be a good alternative to antibiotic tablets for women with bacterial vaginosis (BV) or thrush. Researchers will recruit 114 women and give half lactoferrin vaginal pessaries for 3 weeks, while the othe…

This pilot study is testing whether a light-activated gel applied inside the nose before surgery can prevent infections afterward. Eighty adults having nasal surgery will either get the light treatment or a plain gel. Researchers will track who needs antibiotics for infection wit…

This study tests a new NHS approach to help adults with type 1 diabetes manage diabetes distress—feelings like worry, frustration, or burnout related to their condition. Researchers will train healthcare teams to spot and discuss these emotions during routine visits, and offer an…

This study tests a new type of breathing machine (volume-targeted ventilation) for people with slowly worsening muscle diseases who already use a standard breathing machine at night. The goal is to see if it can better control carbon dioxide levels and improve sleep comfort. Abou…

This study tests whether a 3-month at-home listening training program (BEARS) can help children aged 8 to 16 with two cochlear implants understand speech in noisy environments. Participants will be randomly assigned to receive the training plus usual care or usual care alone. The…

Acute kidney injury affects half of ICU patients, often requiring dialysis. This study compares a lower dose of dialysis to the standard dose in 20 critically ill adults. The goal is to see if the lower dose is safe and effective, and to inform a larger future trial.

This study is investigating whether people with REM sleep behavior disorder (RBD) have a higher history of concussions or contact sports compared to those without RBD. Researchers will interview 140 participants (70 with RBD and 70 without) about their past head injuries and spor…

This study looks at how different sedatives affect the breathing of patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. Twenty adults in the ICU will receive both standard intravenous propofol and inhaled isoflurane (a gas used in anesthesia) for sho…

This study looks at how chronic respiratory failure affects people's quality of life. Researchers will ask 200 patients about their well-being and track changes over time. The goal is to better understand the real-world impact of treatments like breathing machines.

This study aims to understand the immune patterns in the lungs and blood of people with asthma or COPD compared to healthy volunteers. Researchers will collect samples from 230 adults to identify different types of airway disease. The goal is to better understand these common lun…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals. Then, with help from patients, families, and staff, they will design…

This study looks at how to best use a machine that helps people with neuromuscular disease cough and clear mucus from their lungs. Researchers will test different pressure settings to see which works best without causing side effects. About 30 adults with stable or slowly progres…

This study looks at why people with pleural effusion (fluid around the lungs) feel short of breath. Researchers will measure breathing effort and breathlessness before and after fluid removal in 124 adults. The goal is to better understand the connection, not to test a new treatm…

This study looks at how often children develop low blood sugar (hypoglycemia) when they fast before surgery. Fasting is required to prevent choking during anesthesia, but young children have less energy stored and may be at risk. Researchers will measure blood sugar in over 6,500…