Fudan University

Researchers compare two schedules of partial breast irradiation after breast-conserving surgery in women with low-risk early breast cancer. One group receives radiation daily for one week, the other for three weeks. The trial measures breast appearance three years later and track…

Researchers are testing whether adding apatinib, a drug that blocks blood vessel growth, to a CDK4/6 inhibitor and hormone therapy helps control HR+/HER2- advanced breast cancer. The trial enrolls women aged 18 to 75 with confirmed HR-positive, HER2-negative invasive breast cance…

This trial tests whether women with advanced breast cancer (cN3) who had chemotherapy before surgery can safely skip an extra radiation dose to lymph nodes that no longer show signs of cancer. Half of the participants receive the standard extra radiation boost, while the other ha…

This trial studies women with breast cancer who need a mastectomy, radiation, and immediate breast reconstruction using their own abdominal tissue (DIEP flap). The goal is to compare giving radiation before surgery versus after surgery. Researchers will measure patient satisfacti…

This Phase 2 trial is testing an experimental immunotherapy drug called QL1706 combined with standard chemotherapy (nab-paclitaxel and gemcitabine), with or without the targeted drug bevacizumab, as a first treatment for people with advanced pancreatic cancer that cannot be remov…

This trial is testing whether combining the targeted drug trastuzumab with either oral chemotherapy or hormone therapy can effectively treat stage I HER2-positive breast cancer. The study includes women aged 18-70 with small, lymph-node-negative tumors, divided into two groups ba…

This phase 2 trial is testing whether adding PET-guided radiation and an immunotherapy drug called cadonilimab to standard chemotherapy can shrink tumors better than chemotherapy alone in people with colorectal cancer that has spread to the lining of the abdomen. The study will e…

This trial is testing whether giving a PD-1 immunotherapy drug after surgery can help people with a specific type of stomach cancer (MSI-H) live longer without the cancer coming back. Participants who had surgery to remove their stomach cancer will be randomly assigned to receive…

This trial is testing whether a precise, high-dose form of radiation called stereotactic body radiotherapy (SBRT) can control distant metastases in people with stage IV thyroid cancer. The study enrolls patients with up to five metastatic lesions who have already tried systemic t…

This phase 2 trial is testing whether adding surufatinib (a targeted therapy that blocks blood vessel growth) to standard immunotherapy and chemotherapy can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. The treatment is given befor…

This trial is testing whether combining two standard drugs—fruquintinib and TAS-102—can help people with metastatic colorectal cancer that has stopped responding to at least two prior chemotherapy regimens. The study will measure how long patients live without the disease getting…

This trial tests whether combining an immunotherapy drug (tislelizumab) with standard chemotherapy and heated chemotherapy delivered directly into the abdomen can shrink tumors and improve survival in people with stomach cancer that has spread to the lining of the abdomen. The st…

This study tests a combination of the drug abemaciclib with standard chemotherapy (FOLFOX or FOLFIRI) in 16 adults with advanced colorectal cancer that has spread to the liver and hasn't responded to at least two prior treatments. The goal is to see if this combination can shrink…

This study tests whether combining a targeted drug called disitamab vedotin with BCG therapy can improve outcomes for people with HER2-positive high-risk non-muscle invasive bladder cancer. The drug is given intravenously every three weeks, while BCG is delivered directly into th…

This study tests an immunotherapy drug called camrelizumab, given directly into the bladder, for people with high-risk non-muscle invasive bladder cancer that did not respond to BCG treatment. The goal is to find a safe dose and see if it can prevent cancer from coming back or ge…

This study tests a treatment plan for people with muscle-invasive bladder cancer who want to avoid bladder removal. Participants receive chemotherapy plus an immunotherapy drug called tislelizumab, followed by a tailored course of radiation therapy. The goal is to see if this com…

This study is testing whether a short-term, low-calorie diet called a fasting mimicking diet (FMD) can help patients recover better after surgery for colorectal cancer. The diet is given in cycles after the operation and is designed to be easier to follow than complete fasting. R…

This study aimed to compare three different immunotherapy drug regimens given before and after surgery for people with early-stage non-small-cell lung cancer. The goal was to see which approach best prevented the cancer from coming back. However, the trial was withdrawn before en…

This phase II trial tests whether adding an immunotherapy drug (sintilimab) and immune-supporting agents to a medium-dose chemo-radiation regimen can improve outcomes for people with advanced esophageal cancer. About 50 participants will receive the combination, along with probio…

This study tests a combination of three drugs—bevacizumab, nab-paclitaxel, and a platinum drug—as a second-line treatment for people with advanced non-squamous non-small cell lung cancer that does not have certain genetic mutations. The cancer must have worsened after first-line …

This study tests whether giving targeted drugs based on the genetic makeup of a person's advanced salivary gland cancer can shrink tumors or stop them from growing. About 88 adults with cancer that has spread or come back are enrolled. Researchers are checking how well these trea…

This study looks at using a targeted drug called osimertinib together with precise brain radiation as the first treatment for people with a certain type of lung cancer (EGFR-mutant) that has spread to the brain and causes symptoms. Researchers reviewed medical records of 300 pati…

This study tests a two-step treatment for people with early-stage MALT lymphoma, a slow-growing cancer of the lymph nodes. First, patients take a targeted drug called orelabrutinib. Then, based on how well the tumor responds, they receive an ultra-low dose of radiation (4Gy) to a…

This phase 3 trial compares two chemotherapy regimens for women with non-triple negative breast cancer after surgery. One group gets epirubicin plus cyclophosphamide followed by docetaxel (EC-T), the other gets paclitaxel plus carboplatin (PCb). The study includes 1560 participan…

This phase 2 trial tests whether adding the immunotherapy drug cadonilimab (AK104) to standard chemoradiotherapy can improve outcomes for people with stage III non-small cell lung cancer that cannot be removed by surgery. About 41 participants will receive the drug before, during…

This study tests whether adding precise radiation (stereotactic radiosurgery) to standard drug therapy can better control brain metastases in people with non-small cell lung cancer. Participants have brain tumors that remain after 3-6 months of a targeted drug. The goal is to see…

This study looks at whether artificial intelligence can accurately determine the depth of early esophageal cancer from endoscopic images. Researchers will review past records and images from 890 patients who had their tumors removed. The goal is to see if AI can help doctors deci…

This study looks at whether testing stool (feces) for certain DNA changes and bacteria genes can help find stomach cancer early. Researchers will follow 3000 people, including those with and without cancer, to see how well the test works. The goal is to improve early diagnosis an…

This trial tests whether running HEPA air purifiers in classrooms and bedrooms for four months improves heart and lung function in healthy primary school students aged 8 to 12. Researchers will measure heart rate variability, lung capacity, and markers of inflammation in children…

Doctors remove right or left colon cancer along with nearby lymph nodes, but the deep nerves that control the gut often get damaged. That damage can leave patients with lasting diarrhea, bowel spasms, or slow bowel movements. This trial compares standard surgery with a laparoscop…

This trial tests whether an AI-powered chatbot can help reduce anxiety and improve coping in men about to have prostate cancer surgery. Participants will either receive standard preoperative communication or also have access to a large language model (LLM) that answers their ques…

This study tests a nurse-led program that starts at least a week before liver cancer surgery. It includes exercise, nutrition advice, mental support, and help quitting smoking or drinking. The goal is to see if this program helps patients stay stronger, feel less anxious, and hav…

This study tests whether drinking cola can help relieve sudden food blockages in the esophagus for people with esophageal cancer. Fifty participants will be randomly assigned to drink cola or receive standard care, and researchers will check if the blockage clears within 24 hours…

This study, run by Fudan University and local health authorities, uses computer models to predict the best way to use dengue vaccines in Yunnan, China. Researchers will collect blood samples from 220 residents to measure antibody levels and simulate different vaccination scenario…

Researchers at Fudan University are testing whether sitting in a 16°C room for two hours changes heart rate, blood pressure, lung function, or thinking speed in healthy young adults. Each participant will also spend time in a comfortable 22°C room for comparison. The study measur…

Researchers in Shanghai are testing whether breathing traffic-related air pollution during a short walk affects heart and lung function. Healthy young adults will either walk along a busy road or in a traffic-free park for 4.5 hours, alternating walking and rest. The team will me…

Researchers at Fudan University are testing what happens to healthy young adults when they sit in a 32°C chamber for two hours. They will measure blood vessel stiffness, lung function, and mental speed, comparing these to a day spent at a comfortable 22°C. The study aims to revea…

This study combines MRI scans with detailed genetic and molecular analysis (multiomics) to improve how luminal breast cancer is classified and treated. Researchers aim to develop models that predict treatment resistance, recurrence, and spread, helping doctors choose the most eff…

This study explores whether a Nectin-4 PET scan can predict how well a Nectin-4-targeted therapy works in people with advanced breast cancer. Forty participants will receive both a standard PET scan and a Nectin-4 PET scan before starting treatment, and some will have a repeat sc…

This study looks at how anemia changes blood flow in the smallest blood vessels (microcirculation) in patients having open surgery for gastric cancer. Researchers will compare 27 anemic patients with 27 non-anemic patients, all receiving standard goal-directed fluid therapy. They…

This study was designed to see if adding chemotherapy to radiation therapy after incomplete surgery for thymoma or thymic carcinoma could improve survival. It planned to enroll adults aged 18-75 who had incomplete tumor removal. However, the trial was withdrawn before any partici…

This study looks at whether PET-CT scans can predict if non-small cell lung cancer has spread to nearby lymph nodes. Researchers will compare two types of PET-CT scans (using different tracers) with the actual results from surgery. The goal is to see if these scans can help docto…

This study looks at 197 women with advanced breast cancer to compare survival between those whose tumors lost estrogen receptors (ER) and those with triple-negative disease. Researchers used a special PET scan to track receptor changes. The goal is to understand how these changes…

This study looks at whether tiny particles called exosomes, found in blood and lung fluid, can predict how well treatment works in advanced lung cancer patients with fluid buildup around the lungs. Researchers will collect samples from 100 patients before and during standard ther…