Anemia's hidden impact on blood flow during surgery revealed
NCT ID NCT07583927
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how anemia changes blood flow in the smallest blood vessels (microcirculation) in patients having open surgery for gastric cancer. Researchers will compare 27 anemic patients with 27 non-anemic patients, all receiving standard goal-directed fluid therapy. They will use a special camera to view blood vessels under the tongue at four points during surgery. The goal is to see if anemia causes measurable differences in vessel density and blood flow, which could help guide future care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better understand how anemia affects blood flow in small vessels during surgery, potentially improving fluid management for anemic patients.
- What could go wrong
- This is a small, early observational study with only 54 participants. It does not test any treatment, so it cannot directly lead to new therapies. Results may not apply to other surgeries or patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 54 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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May 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of adult patients (age ≥18 years) scheduled for elective open radical gastrectomy for gastric cancer at Fudan University Shanghai Cancer Center. Patients are assigned to two groups based on their preoperative hemoglobin level: anemic group (Hb ≤10 g/dL) and non-anemic group (Hb \>10 g/dL). All patients undergo standardized goal-directed fluid therapy during surgery and receive general anesthesia with endotracheal intubation.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Scheduled for elective open radical gastrectomy * Age ≥ 18 years * ASA physical status I-III * Undergoing general anesthesia with endotracheal intubation Exclusion Criteria: * Untreated ischemic heart disease or severe cardiovascular disease * Acute or chronic respiratory failure, severe asthma, pulmonary bullae, pneumothorax, emphysema, bronchopleural fistula * Oral or tongue disorders * Scheduled for laparoscopic surgery * Inability to position or observe the patient's head during surgery * Refusal to participate after entering the operating room * Intraoperative life-threatening events * Hemodynamic instability during surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Shanghai Cancer Center, Fudan University
Shanghai, Shanghai Municipality, 200030, China
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