Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico

This study looks at how well the drug daratumumab works for people with a rare blood clotting disorder called immune-mediated thrombotic thrombocytopenic purpura (iTTP) when standard treatments fail. Researchers will track 40 patients to see if the drug helps restore normal blood…

This study tests whether a low-FODMAP diet can reduce pain and improve quality of life in 150 women with endometriosis who also have gut symptoms like bloating and constipation. Participants will either follow the diet or continue their usual care. The goal is to see if changing …

This study compares eye drops made from umbilical cord blood plasma to standard artificial tears for treating moderate to severe dry eye disease. About 100 adults with dry eye and corneal damage will receive either the cord blood drops or artificial tears for two months. The goal…

This study looks at how genes influence fat buildup in the liver and whether that fat raises the risk of liver damage and heart problems. Researchers will study 2500 blood donors aged 40-65 who are overweight or have related health issues. The goal is to use genetic information t…

This study follows 650 women with endometriosis who want to have a baby after diagnosis. Researchers compare pregnancy rates and live births between those who had medical treatment versus surgery. The goal is to understand which approach leads to better fertility outcomes.

This study aims to understand how certain genetic changes contribute to a rare liver disease called atypical primary sclerosing cholangitis (PSC). Researchers will create 3D cell models from patient samples to study these genetic factors and test potential treatments. The study i…

This study is looking at the DNA of 2880 people to find genetic clues about why some people with fatty liver disease develop serious liver damage, cirrhosis, or liver cancer. Researchers will compare the genes of patients with advanced disease to those with risk factors but less …

This study looks at whether using a mix of brain scans, spinal fluid analysis, and thinking/movement tests can more accurately diagnose idiopathic normal pressure hydrocephalus (iNPH) and help select the best candidates for shunt surgery. Researchers will follow 116 people aged 6…

This study aims to create a fast T-cell analysis test to help doctors better manage chronic hepatitis B and B/D infections. Researchers will observe 300 patients over time, linking immune responses to disease outcomes. No new treatments are tested; the goal is to improve monitori…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand how genetic factors and lifestyle interact. The goal …

This study aims to find out if tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. About 120 adults with certain cancers will give blood samples and answer questionnaires before, during, and after treatment. The goal is to …

This study looks at how a person's genes and their environment (like alcohol use) together increase the risk of developing liver cancer from alcohol-related liver disease. Researchers will study 1000 people to find new genetic variants linked to this cancer. The goal is to better…

This study will measure the abdominal aorta in 652 women aged 50 and older using ultrasound. Researchers want to learn what a normal aorta size is for women and find out which health factors may increase the risk of an aortic aneurysm. Participants will have one ultrasound and sh…

This study aims to see if a lab-grown cell system can detect a substance in the blood that causes protein leakage in the urine of people with a kidney condition called nephrotic syndrome. Researchers will compare blood and urine samples from 150 participants, including patients w…

This study looks at whether kidney failure changes how well the flu vaccine works in people on dialysis. Researchers will compare the immune response of 146 dialysis patients and healthy volunteers after getting the flu shot. Participants give blood samples over several months to…

This study looks at special cells from blood vessels (called ECFCs) in people with von Willebrand disease, acquired von Willebrand syndrome, and healthy volunteers. Researchers want to see how these cells make and release a key clotting protein. The goal is to better understand t…

This study aims to find genetic reasons why some adults develop cholestatic liver disease, a condition where bile flow is blocked. Researchers will use whole-genome sequencing to analyze DNA from 60 adults with unexplained or atypical symptoms. The goal is to improve diagnosis an…

This study uses tiny, lab-grown liver models (called organoids) made from patient cells to understand how a specific gene variant (PNPLA3 I148M) contributes to non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease. Researchers will expose these mini-livers t…

This study looks at whether blocking two proteins, SUV420H1 and SUV420H2, in liver cells can protect against nonalcoholic fatty liver disease (NAFLD). Researchers will test this in mice, analyze human genetic data, and try a new gene-silencing approach in lab-grown human liver ti…

This observational study aims to understand how the immune system responds to hepatitis D virus (HDV) in people with chronic HBV-HDV infection. Researchers will measure HDV-specific T cell responses in 192 participants before and during treatment with bulevirtide. The goal is to …