First Affiliated Hospital Of Wenzhou Medical University

This study looks at 140 adults with coronary heart disease who need non-emergency non-cardiac surgery. Researchers want to see if it's safer and more effective to open blocked heart arteries before or after that surgery. The goal is to reduce major heart problems like heart attac…

This study tests a drug called risankizumab in 260 adults with fibrostenotic Crohn's disease, a severe form where scarring narrows the intestines. Participants who have not improved with standard treatments will receive either the drug or a placebo. The goal is to see if risankiz…

This study compares two ways to perform a key part of rectal cancer surgery in women. The goal is to see which technique reduces blood loss and improves recovery. About 200 female patients with mid-to-low rectal cancer will take part. The research focuses on finding the safest an…

This study tests whether adding dextromethorphan to the standard drug nidanib helps people with idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring and breathing problems. About 60 adults aged 40 and older with mild to moderate IPF will receive either…

This study tests whether adding a precise, high-dose form of radiation (SBRT) to standard chemotherapy and immunotherapy before surgery can improve outcomes for people with a common type of breast cancer (HR+/HER2-). The trial will enroll 302 adults with high-risk features, such …

This study tests whether giving immunotherapy and chemotherapy at different times, based on daily immune system monitoring, works better than giving them together. 246 adults with advanced non-small cell lung cancer will be assigned to one of three timing schedules. The goal is t…

This study tests if GLP-1 weight-loss drugs (like Ozempic) can improve sperm quality and help obese men conceive naturally. About 180 men aged 20-45 will receive either lifestyle advice, semaglutide, or tirzepatide for 48 weeks. The goal is to see if these drugs boost sperm count…

This early-stage study tests an experimental treatment called CBG131 for adults with advanced stomach or pancreatic cancer that has a specific marker (CLDN18.2). The treatment uses a patient's own immune cells, modified in a lab to better attack cancer. The main goals are to chec…

This study tests whether adding chemotherapy directly into the bladder to an immunotherapy drug (toripalimab) works better than the immunotherapy alone for people with a high-risk bladder cancer that hasn't responded to standard BCG treatment. About 106 adults will be randomly as…

This study tests whether adding inectolizumab to standard steroid treatment can lower the amount of steroids needed by people newly diagnosed with neuromyelitis optica spectrum disorder (NMOSD). The trial will enroll 25 adults who have not yet been treated and are positive for a …

This study tests whether a 12-week steroid treatment works as well as the standard 24-week course for adults having their first episode of steroid-sensitive nephrotic syndrome, a kidney condition causing protein leakage and swelling. About 224 participants will be randomly assign…

This study tests a new, high-tech surgical system for people with knee osteoarthritis. The system uses 3D planning, custom 3D-printed guides, and augmented reality to help surgeons perform more precise knee realignment surgery. Researchers will compare this new approach to tradit…

This study tests whether a medication called edaravone dexborneol can prevent epilepsy in people who have had a stroke. About 160 adults at high risk for post-stroke seizures will receive either the drug or a placebo for up to 2 years. The goal is to see if the drug reduces the c…

This study tests three different digital foot care programs to see which best prevents diabetic foot ulcers in people with diabetes who are at high risk. About 1,500 participants aged 50 to 80 will use smartphone apps and take photos of their feet, with some getting extra support…

This study tests a new surgery that removes only the cancerous upper part of the stomach, instead of the whole stomach. The goal is to help patients lose less weight and have better nutrition after surgery. About 120 adults with early-stage upper stomach cancer will be randomly a…

This study tests whether ondansetron, a drug used for nausea, can lower the risk and severity of side effects from immunotherapy in people with liver cancer. About 134 patients will receive ondansetron or a placebo alongside their standard cancer treatment. The goal is to see if …

This study aims to build an artificial intelligence system that can predict whether a person with advanced liver cancer will respond to a common drug combination (atezolizumab and bevacizumab). Researchers will look back at medical records and CT scans from 400 patients to find p…