First Affiliated Hospital Of Wenzhou Medical University

Researchers are comparing two ways of performing robotic surgery to remove stomach cancer: a single-port approach and a standard multi-port approach. The trial enrolls 212 adults with stomach cancer that can be removed with distal gastrectomy. The main question is whether the sin…

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

Researchers are testing whether adults with obstructive hypertrophic cardiomyopathy can safely taper off beta-blockers after their heart condition has stabilized on mavacamten. The trial enrolls 286 people aged 18 to 75 who have been on a stable dose of mavacamten and one beta-bl…

This study tests whether adding chemotherapy drugs (gemcitabine and mitomycin C) directly into the bladder alongside an immune-boosting drug (toripalimab) works better than toripalimab alone for people with a high-risk bladder cancer that did not respond to standard BCG therapy. …

This study compares starting dotinurad, a urate-lowering drug, during an acute gout flare versus waiting until the flare resolves. About 142 adults with gout will be randomly assigned to one of two timing schedules. Researchers will measure how quickly the flare resolves and whet…

This phase 2 trial tests whether adding dextromethorphan to the standard drug nidanib helps people with idiopathic pulmonary fibrosis (IPF). About 60 adults aged 40 and older will take either the combo or nidanib alone for 12 weeks. The main goal is to see if lung function (FVC) …

This early-stage trial tests an experimental treatment called CBG131 for adults with advanced stomach or pancreatic cancer that has a specific marker (CLDN18.2). The therapy uses a patient's own immune cells, modified in a lab to target and attack cancer cells. The main goals are…

This trial tests a new surgical system for knee osteoarthritis that uses 3D planning, custom guides, and augmented reality to improve alignment and reduce pain. About 150 people aged 40-70 with mild-to-moderate knee arthritis will be assigned to either the new system or tradition…

This study compares a new, less invasive surgery that removes only the cancerous upper part of the stomach to the standard full stomach removal. The goal is to see if the new approach helps patients lose less weight one year after surgery. The trial will enroll 120 adults with ea…

This study tests whether adding targeted radiation (SBRT) to standard chemotherapy and immunotherapy before surgery can improve outcomes for people with a common, high-risk breast cancer type (HR+/HER2-). About 302 participants will be randomly assigned to receive either chemo-im…

This clinical trial is testing whether giving immunotherapy a few days after chemotherapy, instead of on the same day, can improve outcomes for people with advanced non-small cell lung cancer. The study will enroll 246 adults and compare three different timing schedules, includin…

This trial compares two surgical techniques for removing rectal cancer in women. The standard method cuts the peritoneum slightly above its lowest point, while the new method cuts exactly at the lowest point. Researchers believe the new technique may reduce blood loss and protect…

This Phase 3 trial will test two drugs, risankizumab and ustekinumab, in 260 adults with fibrostenotic Crohn's disease—a form where the bowel becomes scarred and narrow. The study compares how well each drug prevents further scarring over three years. Participants will receive ei…

This study looks at 140 heart disease patients who also need a non-emergency surgery. Half will get a heart artery-opening procedure (PCI) before their surgery, and half will have it after. The goal is to see which timing leads to fewer heart attacks, deaths, or repeat procedures…

This study tests whether two popular weight-loss drugs, semaglutide and tirzepatide, can improve sperm quality and help obese men have children naturally. About 180 men will receive either lifestyle advice, semaglutide, or tirzepatide for 32 weeks. Researchers will measure change…

This study tests a drug called inebilizumab combined with a fast steroid taper in 25 people newly diagnosed with neuromyelitis optica spectrum disorder (NMOSD), a rare autoimmune disease that attacks the optic nerves and spinal cord. The goal is to see if this approach can reduce…

This study compares a 12-week steroid course to the standard 24-week course for adults with steroid-sensitive nephrotic syndrome, a kidney condition that causes protein leakage and swelling. Researchers want to see if the shorter treatment can keep the disease from coming back ju…

Researchers are testing whether a nasal catheter that diverts stool from the small intestine can prevent leaks after surgery for mid to low rectal cancer. The trial compares this catheter approach with a standard protective ileostomy, a temporary opening in the abdomen to divert …

This study tests whether a tablet called edaravone dexborneol can prevent epilepsy in people who have had a stroke and are at high risk. About 160 adults will receive either the tablet or a placebo for three months, starting within 48 hours of their stroke. Researchers will track…

This study tests whether digital tools, including AI image analysis, can help prevent foot ulcers in people with diabetes at high risk. Over 1,500 participants will be assigned to standard care or one of two digital care programs with different levels of support. The goal is to s…

Researchers compare two methods for replacing a missing front upper tooth with an implant right after extraction. One method, the Socket-Shield technique, leaves a thin piece of the tooth root in place to help protect the jawbone and gums. The other method uses the standard appro…