Centre Hospitalier De L'université De Montréal (chum)

This early-stage trial is testing whether antibodies created in a lab from a patient's own tumor can help the immune system attack and kill cancer cells. The antibodies are designed to target specific markers on cancer cells that are not found on healthy cells. Participants with …

This study tests whether adding a heat treatment (thermal ablation) to the standard procedure for removing large colon polyps can lower the chance they grow back. About 752 adults will be randomly assigned to receive either standard removal alone or standard removal plus burning …

This pilot study tests whether it is safe and feasible to skip surgery in patients with stage II-III non-small cell lung cancer who have a complete response to chemotherapy and immunotherapy. Fourteen participants will be randomly assigned to either observation or standard surger…

This trial compares two surgical techniques for treating corneal basement membrane dystrophy, a condition that causes blurred vision and painful eye erosions. One method is manual scraping of the damaged corneal layer; the other uses a laser to remove it. The study aims to find w…

This study looks at stroke patients who have small clots remaining in smaller brain arteries after the main clot has been removed. Half will get an extra procedure to remove those leftover clots, while the other half will receive standard care without extra intervention. The goal…

This study tests whether daily adaptive radiotherapy (ART) can safely deliver shorter, more intense radiation treatments for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to standard radiation or ART, which uses daily imagin…

This pilot trial tests whether a structured ultrasound assessment can help doctors manage fluids better in patients recovering from cardiac surgery. Participants are randomly assigned to either standard care or an ultrasound-guided strategy that measures fluid tolerance and respo…

This study is testing whether a blood test can detect DNA fragments shed by large, precancerous colorectal growths called laterally spreading tumors (LSTs). Researchers will collect blood samples from 110 adults before they undergo endoscopic removal of these lesions, then analyz…

This trial tests whether an AI system called GI Genius can help doctors accurately tell apart small colorectal polyps (5 mm or less) during a colonoscopy—identifying which ones are harmless versus those that need monitoring. For each small polyp, doctors first record their own di…

Researchers are testing two mobile app-based programs, CHAMPS and iCanChange, for young adults with first-episode psychosis who use cannabis. CHAMPS targets safer use for people not looking to quit, while iCanChange supports those who want to reduce or stop. The trial compares ea…

This pilot study explores whether surface-guided radiotherapy (SGRT) can help head and neck cancer patients who feel anxious or claustrophobic during standard radiation treatment. Instead of a tight thermoplastic mask, SGRT uses a camera system to track patient position in real t…

This study tests whether wearing a special cast for one week can improve thick, itchy burn scars. Researchers will compare treated scars to untreated ones in 38 adult burn survivors. They will measure changes in scar thickness, redness, moisture, itching, and pain.

This study will compare two surgical techniques for trigger finger, a condition where a finger gets stuck in a bent position. One method makes a small cut in the tendon sheath, while the other removes a piece of it. Researchers want to see which approach leads to fewer recurrence…

This early-stage trial tests a new robotic surgical method for esophageal cancer that avoids cuts between the ribs, which may cause less chest pain and faster recovery. About 31 adults with stage I to III esophageal cancer will be randomly assigned to either the new approach or s…

This study tests whether a structured recovery program helps people who have heart surgery with a heart-lung machine recover faster. The program includes steps before, during, and after surgery to reduce pain, lower opioid use, and shorten hospital stays. About 92 adults having t…

About 1 in 10 people who have noncardiac surgery experience a heart injury, which raises their risk of death within 30 days. This pilot study will test whether routinely referring these patients to a heart specialist (internist or cardiologist) helps them get the right medication…

This study will give 80 healthy adults who use cannabis occasionally different low doses of inhaled CBD (5 to 100 mg) or a placebo to see if they feel a pleasant effect. Each person will try all doses in a random order, and researchers will also explore if current tools miss any …

This study will compare two surgical techniques for treating pain after a finger amputation: reconnecting the nerve (microanastomosis) versus cutting and burying it (traction neurectomy). Researchers will track pain levels and hand function in 50 adults over six months. The goal …