Cancer Trials Ireland

This study compared two radiation methods for women with early-stage breast cancer after lumpectomy: 3D conformal radiation therapy (external beams) and multi-catheter brachytherapy (internal radiation). The goal was to see which better kills leftover cancer cells while sparing h…

This study tested a combination of two drugs, denosumab and enzalutamide, in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if the combination could slow cancer growth better than historical results wi…

This study tested whether combining two drugs, trametinib and hydroxychloroquine, could help overcome treatment resistance in people with advanced pancreatic cancer that had spread. The trial aimed to see how many patients were free of cancer growth after 12 weeks. It included 20…

This study tested whether giving a higher dose of radiation directly to the main tumor, while keeping standard doses to surrounding areas, is safe for people with non-small cell lung cancer. Six participants received targeted radiation plus standard chemotherapy. The goal was to …

This study looked at 92 women with high-risk endometrial cancer who needed pelvic radiation after surgery. It compared a newer, more precise radiation method (IMRT) with the standard 3D technique to see if it could reduce side effects like bowel and bladder problems. The goal was…

This study compared two types of radiation therapy given before surgery for locally advanced rectal cancer. The goal was to see if one method caused fewer stomach and bowel side effects. About 94 people took part, but the study was stopped early.