Cancer Trials Ireland

This early-phase trial tested a combination of two drugs—copanlisib and trastuzumab—in 26 women with advanced HER2-positive breast cancer that had worsened after prior treatment. The goal was to find the safest dose and see if the combination could shrink tumors or slow disease p…

This study tested whether giving two drugs together—Radium-223 and enzalutamide—is safe for men with advanced prostate cancer that has spread to other parts of the body and is no longer controlled by standard hormone therapy. 45 men took part. The main goal was to track serious s…

This study tested a drug combination (abiraterone acetate plus prednisolone and hormone therapy) given before radiation in 45 men with high-risk localized prostate cancer. The goal was to see if the treatment could shrink tumors and lower PSA levels. The approach aims to improve …

This completed study looked at 29 people with a specific, hard-to-treat type of advanced colorectal cancer. The goal was not to test a new drug, but to find better ways to group patients based on the biology of their cancer. Researchers hope this will help doctors choose the righ…

This study looked at 76 adults with advanced colorectal cancer to find genetic markers that might predict how well a combination of chemotherapy (FOLFOX) and the drug bevacizumab works. The goal was to understand which patients benefit most, not to test a new cure. Participants h…

This completed study looked at whether it is practical to routinely test tumor tissue and blood for BRCA1/2 gene mutations in patients with high-grade serous or endometrioid ovarian, fallopian tube, or primary peritoneal cancer. Researchers enrolled 200 patients in Ireland to see…

This study looked at whether a special tumor test (called the 21 gene Recurrence Score) changes doctors' decisions about recommending chemotherapy for women with a common type of early breast cancer. 87 patients in Ireland took part. The goal was to see if the test could help avo…