TYPE 1 DIABETES (T1D)

This study looks at whether using ultrasound to find fatty lumps (called lipohypertrophy) caused by insulin injections can help people with diabetes better control their blood sugar. About 50 adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor w…

This study tests whether automated insulin delivery (AID) systems can safely manage blood sugar during labor and delivery for pregnant people with type 1 diabetes. About 150 participants will be randomly assigned to use their own AID system or standard intravenous insulin. The go…

This early-phase study tests a new treatment called OPF-310, which uses pig islet cells (the cells that make insulin) placed inside tiny capsules. The goal is to see if transplanting these cells is safe and can help adults with unstable type 1 diabetes who still have dangerous lo…

This early-stage study tests a new treatment called GNTI-122, made from a person's own blood cells, in 16 adults recently diagnosed with type 1 diabetes. The goal is to see if it is safe and how it affects the body's ability to produce insulin. Participants receive one dose and a…

This study tests whether adding a weekly medicine called tirzepatide to standard insulin therapy helps adults with type 1 diabetes control their blood sugar better. About 42 people aged 18-65 who already use an automated insulin pump will take part. The goal is to see if the drug…

This study tests a very low-calorie ketogenic diet (600-800 calories per day) in 14 adults with type 1 diabetes and obesity who use an automated insulin pump. The goal is to see if the diet can help them lose about 5% of their body weight in 4 weeks without causing dangerous drop…

This study tests an experimental drug called CIR-0602K in 40 adults with type 1 diabetes who already use an automated insulin pump. The goal is to see if the drug helps them keep their blood sugar in a healthy range more often and reduces how much insulin they need each day. Part…

This study compares a smart insulin pump called the iLet Bionic Pancreas to usual diabetes care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the pump or continue their routine care for 13 weeks to see if the pump improves blood sugar …

This study looks at whether a community health worker (CHW) can help Black children with type 1 diabetes better manage their blood sugar using automated insulin pumps. Sixteen children and their families will meet with a CHW coach for six months, then be followed for another six …

This study from the University of Oxford is testing whether a simple finger-prick test done at home can replace the standard oral glucose tolerance test (OGTT) for diagnosing type 1 and type 2 diabetes in children and young people. The standard OGTT requires a vein drip and multi…

This study aims to identify children and adults (ages 1-45) who are at increased risk of developing type 1 diabetes by testing for specific markers in the blood called autoantibodies. Participants must have a family member or close friend diagnosed with type 1 diabetes before age…

This study tests a mindfulness app called Calm Health in 10 young adults (ages 18-30) with type 1 diabetes. Participants use the app and get feedback on how their mindfulness relates to blood sugar, stress, and sleep. The goal is to see if the app is easy to use and helps ease di…

This study is testing a virtual peer support program for 300 people in Canada living with type 1 diabetes (or their loved ones). Participants join small online groups based on shared experiences (like age, background, or life stage) and attend monthly webinars. The goal is to red…

This study tests a mobile app that gives personalized tips and insights based on your blood sugar, exercise, mood, and sleep patterns. The goal is to help 60 adults aged 30-65 with type 1 diabetes or similar conditions exercise more often and with greater confidence. All particip…

This study looks at how exercising in hot conditions (40°C) changes blood sugar levels in people with type 1 diabetes compared to a normal temperature (20°C). Thirty-eight adults with type 1 diabetes who exercise regularly will do moderate-intensity exercise in both conditions. R…

This study is collecting kidney tissue samples from 1,000 people with acute kidney injury or chronic kidney disease, including those with diabetes. Researchers will use advanced technology to analyze the tissue and identify different disease subtypes. The goal is to better unders…

This study looks at how blood sugar levels change during exercise in healthy adults and those with type 1 diabetes. Researchers want to see if these changes are similar each time a person exercises. Participants will cycle or rest after a standard breakfast, and their glucose wil…

This study looks at how sleep apnea (pauses in breathing during sleep) affects blood sugar levels in adults with type 1 diabetes. Researchers will monitor 40 participants using continuous glucose monitors to see if sleep apnea makes blood sugar harder to control. The goal is to b…

This study is monitoring the safety and performance of the Twiist insulin delivery system in 1,875 adults and children (ages 6 and up) with type 1 diabetes. Participants are already using the Twiist system, and researchers will track severe low blood sugar events, diabetic ketoac…

This study looks at 36 adults with type 1 diabetes who have received a pancreatic islet transplant. Researchers want to see if a continuous glucose monitor (CGM) can detect early loss of the transplant's function. They will track a measure called "Time in Tight Range" (blood suga…

This study looks at whether sexual activity increases the risk of low blood sugar (hypoglycemia) in adults with type 1 or type 2 diabetes who use insulin and a continuous glucose monitor (CGM). One hundred participants will mark sexual activity in their CGM app for 3 months. Rese…