TYPE 1 DIABETES (T1D)

This study will test a new experimental insulin delivery system (NMX8) in 230 adults with type 1 diabetes who are not meeting their blood sugar goals with current automated insulin pumps. The goal is to see if the NMX8 system is safe and helps keep blood sugar in a healthy range …

This early-stage study tests a new drug, IMC-S118AI, in adults with type 1 diabetes who have a specific genetic marker (HLA-A*02:01). The goal is to see if the drug is safe and can help preserve the body's remaining ability to produce insulin. Up to 154 participants will receive …

This study tests a smartphone app called DailyDose that helps people with type 1 diabetes manage their blood sugar. The app uses data from a continuous glucose monitor, insulin use, and exercise to give personalized advice on insulin doses and carbs during exercise or low blood s…

This study tests whether wearing a continuous ketone monitor alongside a continuous glucose monitor can reduce the risk of a serious side effect (high ketones) from the drug sotagliflozin in people with type 1 diabetes. About 52 adults will take two different doses of the drug wh…

This study tests whether a computer program called MODI can safely help adults with type 1 diabetes adjust their insulin doses. About 36 people who use daily insulin injections and a continuous glucose monitor will try the algorithm for 13 weeks. The main goal is to see if the pr…

This study tests a mobile app called Diactive-1 that provides personalized exercise and education for children and adolescents with type 1 diabetes. The app uses a simple handgrip strength test to tailor recommendations. The goal is to help young patients better manage their diab…

This study looks at 14 people with type 1 diabetes who use the MiniMed 780G insulin pump. They will do a supervised strength training session twice, once with the pump in SmartGuard mode and once with a temporary target setting. The goal is to see which setting keeps blood sugar …

This study will test whether providing medically tailored meals or fresh produce prescriptions, along with nutrition coaching, can improve diet quality and blood sugar control in 12 families with school-age children who have type 1 diabetes and face food insecurity. The goal is t…

This study tests a new patch with tiny needles that measures both ketones and glucose continuously in people with type 1 diabetes. Ten participants will wear the patch on their arm while their insulin pump is paused for 3 hours. The goal is to see if the patch readings match stan…

This early-stage study tests a new medicine, NNC0497-0040, given as a weekly shot. It will include healthy people, those who are overweight or obese, and people with type 1 diabetes who are also overweight. The main goal is to check if the drug is safe and tolerable, and how the …

This study tests a toolkit that gives personalized advice on when to exercise, adjust insulin, and eat carbs to keep blood sugar stable. Twenty adults with type 1 diabetes will try three different pre-exercise plans, including one guided by the toolkit. The goal is to see if the …

This study tests if a single-session depression program can help teens with type 1 diabetes improve their mood and blood sugar control. About 80 youth aged 11-18 with mild depression will either get the program or standard education. Researchers will check mood and HbA1c levels o…

This study tests a three-part training program for older adults (65+) with diabetes who use insulin. The program teaches CGM technology, data skills, and lifestyle adjustments to improve glucose monitoring and reduce diabetes-related distress. 150 participants will be compared to…

This study follows 300 children and adults who have tested positive for islet autoantibodies, early markers of type 1 diabetes, for up to 10 years. Researchers will track how these markers change over time and whether screening can reduce severe complications at diagnosis. The go…

This study will see if an e-learning app for school nurses is easy to use and helpful. About 86 school nurses in Pennsylvania will use the app over 16 weeks and answer surveys. The goal is to boost their confidence and knowledge about diabetes devices like insulin pumps and conti…

This study will see if it's possible to screen close relatives of people with type 1 diabetes for early signs of the disease. About 1,000 adults in Quebec will provide blood samples and answer questions. If they test positive, they'll be offered follow-up monitoring to track thei…

This study looks at how the timing of insulin doses before meals affects where fat is stored in the body. Ten adults with type 1 diabetes will have their fat storage measured after different insulin timings or skipping a dose. The goal is to understand how insulin timing influenc…