TOBACCO USE

This study aims to see if e-cigarettes or oral nicotine pouches work better to help persistent smokers reduce their cigarette smoking. Researchers will enroll 200 adult smokers who have tried to quit before but haven't succeeded. Participants will be randomly assigned to use eith…

This study is testing a new strategy to help people with HIV who smoke. It focuses on reducing harm from smoking, not just quitting. The approach includes helping people cut down, getting screened for lung cancer, and managing blood pressure and cholesterol to prevent heart disea…

This study is testing whether offering smokers who aren't ready to quit a choice of alternative nicotine products (like e-cigarettes, heated tobacco, or nicotine pouches) helps them reduce or stop smoking cigarettes. Participants will receive a 4-week supply of their chosen produ…

This study is testing whether switching to very low nicotine cigarettes helps people with chronic pain and opioid use disorder reduce their smoking. Researchers will compare these special cigarettes to regular cigarettes to see which better reduces cravings, withdrawal symptoms, …

This study aims to find out if switching completely to e-cigarettes (vapes) is a better way to help people quit smoking while they are in treatment for substance use disorders, compared to using standard nicotine patches and lozenges. It involves 240 adults in South Carolina who …

This small pilot study is testing whether giving cancer patients an indoor air quality monitor helps them keep their homes smoke-free. Researchers want to see if using the monitor for two weeks is practical and if patients attend related workshops. The goal is to improve air qual…

This study is testing if a cannabis compound called CBD, taken as a pill, can help people quit smoking tobacco. Researchers at Johns Hopkins will give CBD or a placebo to 50 adult smokers who want to quit, and measure if it helps them stay smoke-free during short practice quit at…

This study is testing whether a longer, more intensive support program helps people experiencing homelessness quit smoking. It compares 6 months of coaching and nicotine patches to a standard 3-month program. The goal is to see which approach leads to more people successfully qui…

This study is testing whether the flavor of an e-cigarette makes it easier for long-term smokers to switch from regular cigarettes. Researchers will give 210 persistent smokers either fruit, tobacco, or menthol flavored e-cigarettes to use for six weeks instead of smoking. The go…

This study aims to prevent cancer by helping people quit smoking. Researchers are comparing two different digital support strategies to see which one better helps 5,000 adult smokers receive treatment (like medication or counseling) and successfully quit. The trial is testing whe…

This study is testing if switching from regular cigarettes to a tobacco heating system (THS) can help adults with COPD feel better. It will compare people who switch to THS with those who keep smoking cigarettes, looking for changes in coughing, shortness of breath, and lung func…

This study aims to understand how different flavored cigarillos affect smoking habits and appeal among young adults. Researchers will observe 300 participants aged 18-24 who currently smoke cigarillos, measuring their smoking behavior and asking about their experiences with vario…

This study aims to understand how a structured approach to managing heart health risks works in everyday doctor's offices. Researchers will observe 220 adults who already have risk factors like high blood pressure or diabetes, but will not change their current treatments. The goa…

This study aims to understand why people with chronic pain find it harder to quit smoking. Researchers will use brain scans and smartphone surveys to see how temporary smoking withdrawal changes pain signals in the brain and affects quit attempts. The goal is to gather informatio…

This study aims to understand how very low nicotine cigarettes affect the heart compared to regular cigarettes. Researchers will measure heart rate and electrical activity in 49 smokers while they smoke different types of research cigarettes. The goal is to gather information to …

This study aims to understand how THC, the main active ingredient in cannabis, affects a person's desire to smoke cigarettes and their actual smoking behavior. Researchers at Johns Hopkins will give 100 adult participants who regularly use both cannabis and cigarettes different d…

This study aims to understand if relighting a cigarette produces more harmful chemicals than smoking it without stopping. Researchers will observe 30 adult smokers who regularly relight cigarettes, measuring the smoke they produce and asking about their experience. The goal is to…

This study aims to understand how different oral nicotine products affect smokers compared to their usual cigarettes or nicotine gum. It will measure cravings, feelings, and nicotine levels in the blood. About 40 adult smokers will stay at a clinic for several days to try differe…

This study aims to understand what happens in the body when people use marijuana and tobacco together. Researchers will measure drug levels in the blood and physical effects like heart rate in 48 healthy adults who regularly use both substances. The goal is to gather foundational…