TOBACCO USE

This study tests a harm reduction strategy for 400 people with HIV who smoke cigarettes. Instead of pushing for complete quitting, it helps participants cut down, get screened for lung cancer, and manage blood pressure and cholesterol. The goal is to improve overall health and re…

This study tests two counseling approaches—Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement—to help people on methadone treatment reduce tobacco smoking and other drug use. Researchers will enroll 420 adults who are on methadone and smoke cigarettes. The go…

This study tests a program to help people experiencing homelessness stop smoking. It combines coaching sessions with nicotine replacement therapy (like patches or gum). Researchers will check if participants attend sessions, use the therapy, and stay smoke-free at 3 and 6 months.…

This study tests whether giving smokers who aren't interested in quitting a choice of less harmful nicotine products (like e-cigarettes or nicotine pouches) can help them reduce or stop smoking. About 472 adult smokers will be randomly assigned to try either a harm-reduction prod…

This study is testing a program to help cancer survivors and their family members or caregivers quit using tobacco or nicotine products. The program includes personalized support for quitting and training for healthcare providers on how to talk to patients about tobacco use. Abou…

This study tests whether switching to e-cigarettes (nicotine vapes) helps people in treatment for substance use disorder quit smoking better than FDA-approved nicotine patches and lozenges. About 240 adults who smoke and are in outpatient addiction treatment will participate for …

This study looks at whether a structured clinical and medication management plan can improve heart health in adults with risk factors like high blood pressure, diabetes, and high cholesterol. Researchers will track 220 patients in a regular cardiology clinic to see if this approa…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study tests whether using mobile health (mHealth) tools helps find oral cancer and pre-cancer earlier than traditional screening methods. Over 5,000 adults in rural Varanasi, India, who smoke, chew tobacco, or drink alcohol will be screened. The goal is to improve early dete…

This study compares two approaches to help adults stop using tobacco and lower their cancer risk. About 5,000 people who smoke will get either extra reminders and support or standard quit advice. The goal is to see which method leads to more people using medication, counseling, o…

This study tests whether a non-invasive brain stimulation technique called TMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to specific brain areas involved in cravings and self-control. About 64 adults who smoke at least 10 cigarettes a d…

This study is testing whether a compound from cannabis called cannabidiol (CBD) can help people stop smoking tobacco. Researchers will give oral CBD to 50 adults who smoke at least 10 cigarettes daily and want to quit. The goal is to see if CBD increases short-term tobacco abstin…

This study looks at how smoking little cigars affects levels of harmful chemicals and stress on the body compared to regular cigarettes. Fifty daily smokers will try two types of little cigars and their usual cigarette. Researchers will measure markers of oxidative stress and nic…

This study looks at how quitting smoking temporarily increases pain, especially in people with chronic pain. Researchers will use brain scans to see how withdrawal changes pain processing and whether this makes it harder to stay smoke-free. The goal is to find better ways to help…

This study compares e-cigarettes and oral nicotine pouches to see which one helps smokers reduce or stop smoking cigarettes. Two hundred adult smokers who have tried to quit before will be randomly assigned to use either e-cigarettes or nicotine pouches for six weeks. Researchers…

This study looks at brain activity in smokers trying to quit, to understand what leads to a lapse (smoking again). Researchers will use MRI scans to track changes in brain patterns and mood just before a lapse happens. The goal is to find early warning signs that could help preve…

This study looks at whether giving cancer patients an indoor air quality monitor can help them keep their homes smoke-free. Ten patients who smoke and are already in a tobacco treatment program will use the monitor for two weeks. The goal is to see if the device is easy to use an…

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes and how their bodies react. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and cannabis. They will measure cigarette cravings, hea…

This study aims to understand whether relighting a cigarette (instead of smoking it all at once) increases the amount of harmful chemicals smokers inhale. Researchers will observe 30 smokers who regularly relight, measuring their smoking habits and collecting cigarette butts. No …

This study looks at how THC (the active part of cannabis) changes people's desire for e-cigarettes and their body's reactions. Researchers will give different doses of THC or a placebo to 100 adults who regularly use both e-cigarettes and cannabis. They will measure how many puff…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. About 210 adult smokers who have tried to quit before will be given fruit, tobacco, or menthol flavored e-cigarettes for six weeks. Researchers will track how many cigarettes they…

This study looks at how very low nicotine cigarettes change heart rate and heart rhythm in people who smoke daily or occasionally. About 49 adult smokers will have their heart activity measured before and after smoking different types of research cigarettes. The goal is to unders…

This study looks at how cannabis and tobacco affect the body when used together. Researchers will measure levels of THC and nicotine in the blood of 48 regular users who smoke or vape both substances. The goal is to understand the combined health risks and inform public health gu…

This study looks at how addictive five new oral nicotine products are. About 40 healthy smokers, aged 21 to 60, will use the products in a clinic and report their feelings while researchers measure nicotine levels in their blood. The goal is to understand the products' abuse pote…

This study looks at whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in daily smokers who have chronic pain and are on buprenorphine for opioid use disorder. About 60 participants will be randomly assigned to either very low nicotine or …

This study recruits 300 young adults aged 18-24 who smoke cigarillos to understand how different flavors influence their smoking behavior and perceptions. Researchers will measure puff counts and self-reported rewards from smoking, and simulate what might happen if certain flavor…