Tobacco use

This study tests whether a personalized letter and proactive phone calls can help veterans with a newly diagnosed lung nodule quit smoking. The program uses the diagnosis as a 'teachable moment' to motivate quitting. Researchers will compare how many veterans use cessation servic…

This trial tests whether quitting tobacco for 7 days or 21 days changes how much cannabis people choose to smoke. Adults aged 18 to 60 who use both cannabis and tobacco will be randomly assigned to one of two tobacco cessation periods. Researchers will then measure how many canna…

This study looks at whether sending reminders (nudges) to doctors, patients, or both can increase the number of people with HIV who smoke getting help to quit. About 500 patients and their doctors are involved. The goal is to see if these nudges lead to more referrals and partici…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study tests a proactive, culturally tailored outreach program to help BIPOC adults who smoke quit tobacco. Researchers will enroll 700 participants from two health systems and provide personalized materials and support to connect them with proven cessation treatments. The go…

This study compares two approaches to helping smokers quit: an opt-out method where everyone is automatically referred unless they say no, versus an opt-in method where people must actively sign up. Over 1,300 veterans at VA clinics in New York are taking part. The goal is to see…

This study tests a program called BAT-CS that combines smoking cessation counseling with mood management for people who have had a heart attack (acute coronary syndrome). The goal is to help them quit smoking and reduce depression symptoms, which could lower their risk of dying f…

This study compares two ways to help people stop smoking and lower their cancer risk. About 5,000 adults who smoke and visit a participating clinic will be assigned to either a program that uses personalized reminders and support (ELEVATE-S) or standard quit-focused care (ELEVATE…

This study tests a program called Journey of Transformation for Native American tenth graders at an off-reservation boarding school. The program uses traditional storytelling, cultural arts, and outdoor activities to teach leadership and healthy decision-making around substance u…

This study tests whether a robot-assisted escape room game can help 5th and 6th graders learn about the harms of tobacco and e-cigarettes. About 200 students in Taiwan will either play the game or receive standard classroom lessons. Researchers will measure changes in knowledge, …

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study tests whether a short group therapy program (CBT) can help men in prison stop smoking. 202 participants will be randomly assigned to CBT, a health education session, or a waitlist. Researchers will check if they quit by measuring carbon monoxide levels at 1 and 3 month…

This study aims to understand if relighting a cigarette (smoking it in parts) produces more harmful chemicals than smoking it all at once. Researchers will observe 30 smokers who already relight their cigarettes, measuring their smoking habits and collecting cigarette butts. No t…

This study looks at how proposed tobacco regulations might affect the buying and use habits of people in Appalachian Kentucky. About 473 adults who use tobacco daily will take online surveys and shop in a pretend online store where prices change. The goal is to see if rules like …

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study looks at how different tobacco products, like cigarettes, e-cigarettes, and smokeless tobacco, affect the way skin wounds heal. Researchers will measure skin temperature, blood flow, and signs of inflammation in 60 participants, including a non-smoking group. The goal …