SYSTEMIC LUPUS ERYTHEMATOSUS

This early-stage study tests a new treatment called P-CD19CD20-ALLO1 for people with severe lupus that hasn't improved with standard therapies. The treatment uses specially engineered immune cells to target and destroy faulty B-cells, which drive lupus activity. About 162 adults …

This early-stage study tests a new treatment called HN2302 in 12 adults with autoimmune diseases like lupus or scleroderma. The therapy uses the body's own immune cells, modified to target and reduce harmful immune activity. The main goal is to check safety, while also seeing if …

This early-phase study tests a new treatment called QT-019C, which uses specially engineered immune cells (CAR T-cells) from a donor to target and attack faulty cells in people with severe lupus or inflammatory myopathy that hasn't responded to standard therapies. The main goals …

This study tests a new treatment called CD19 UCAR-T cells for people with autoimmune diseases like lupus, vasculitis, and Sjögren's syndrome. The goal is to see if it is safe and can control the disease. About 24 adults aged 18 to 65 will take part. The treatment uses modified im…

This study tests whether adjusting the dose of an immunosuppressant drug (mycophenolate mofetil) based on regular blood tests helps more people with lupus kidney disease achieve remission. One hundred adults with active lupus nephritis will be randomly assigned to either standard…

This early study tests a new treatment called CHT105 for people with severe lupus that has not responded to standard therapies. CHT105 uses donor immune cells engineered to find and destroy the faulty immune cells driving the disease. The main goals are to check safety and see if…

This study compares two drugs, telitacicept and belimumab, for controlling systemic lupus erythematosus (SLE) in 180 adults aged 18-65. Participants choose their treatment with their doctor. The goal is to see which drug better reduces lupus activity and improves kidney outcomes.…

This study tests a new drug called TQH3906 for people with systemic lupus erythematosus (SLE), a chronic autoimmune disease. About 198 participants will receive either the drug or a placebo to see if it reduces lupus symptoms safely. The main goal is to measure improvement using …

This study tests whether a diet tailored to a person's genetic makeup can help control lupus and improve quality of life. About 100 adults with lupus will be screened for specific genes (HLA DQ2 and DQ8) and then randomly assigned to either a personalized diet plan or no special …

This study looks at whether virtual Reiki therapy can help ease pain and improve quality of life for people with lupus. Twenty adults with lupus will continue their usual care and also receive one virtual Reiki session each week for 8 weeks. Researchers will measure changes in pa…

This study looks at how the lupus medication Saphnelo (anifrolumab) is being used in women aged 15 to 50 who could become pregnant. The goal is to collect real-world information to better understand the drug's safety during pregnancy. No new treatments are given; researchers will…

This study aims to understand why certain immune cells (B cells) attack the body in autoimmune diseases like lupus and scleroderma. Researchers will analyze blood samples from 200 adults to identify and measure these harmful cells. The goal is to improve future treatments by targ…

This study is creating a large collection of medical data and blood samples from 450 adults with autoimmune diseases (rheumatoid arthritis, lupus, or scleroderma) and 50 healthy volunteers. Researchers will use advanced lab techniques to find biological patterns that distinguish …

This early-stage study will test the safety and tolerability of a new drug called ACT100 in 48 healthy adults. Participants will receive either the drug or a placebo, and researchers will monitor for side effects and measure how the drug moves through the body. This is the first …

This study looks at how a type of cell death called ferroptosis, which is linked to iron, plays a role in systemic lupus erythematosus (SLE). Researchers will measure certain markers in immune cells from 120 adults with lupus, comparing them to people with other inflammatory dise…