SYSTEMIC LUPUS ERYTHEMATOSUS

This early-stage study tested a drug called telitacicept in 16 children with lupus. The goal was to measure how the drug moves through the body and to check for safety. This is not a cure, but a step toward better control of the disease.

This study followed over 3,000 adults with active lupus for up to 5 years to see how safe and effective Benlysta (belimumab) is when added to standard treatment. Researchers tracked serious side effects like infections, cancer, and psychiatric events. The goal was to understand r…

This study tested whether a single infusion of stem cells from donated umbilical cords could help adults with severe lupus that wasn't responding to standard treatments. 81 participants received either the stem cells or a placebo, plus their usual care. The main goal was to see i…

This study tested an experimental drug called nipocalimab in 228 adults with active systemic lupus erythematosus (SLE). Participants received either the drug or a placebo to see if it could reduce lupus symptoms and disease activity. The goal was to control the disease, not cure …

This study tested an experimental drug called KZR-616 in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). The goal was to see if the drug is safe and can reduce kidney damage. Participants received weekly injections for 13 or 24 weeks. The result…

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already been treated with the IV form for 48 weeks. The goal was to see how the drug moves through the body and if it is safe when given as a shot under the skin. Sixteen chi…

This study tested a daily pill called cenerimod in 427 adults with moderate to severe systemic lupus erythematosus (SLE). The goal was to see if it could safely reduce lupus disease activity over 6 months compared to a placebo. Participants continued their usual lupus medications…

This study looked at how safe and effective Benlysta is for people with lupus when used in normal medical practice. Over 1,500 patients were followed for one year. Researchers tracked side effects, disease activity, and quality of life to ensure the drug works well outside of con…

This study tested a drug called emapalumab in 33 children and adults with a dangerous immune overreaction (macrophage activation syndrome) caused by Still's disease or lupus. The goal was to see if the drug could calm the immune system and improve blood test results when standard…

This study tested a drug called tofacitinib in 13 young adults aged 18 to 45 with lupus that causes moderate to severe skin rashes. The goal was to see if the drug is safe and can help clear skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how we…

This early-stage study tested a new drug called SHR-2173 in 30 adults with systemic lupus erythematosus (SLE). The main goal was to see if multiple injections under the skin are safe and how the drug moves through the body. Participants received the drug and were monitored for si…

This study looked at the long-term safety of an experimental drug called BMS-986165 in people with systemic lupus erythematosus (SLE). A total of 261 adults who had already completed an earlier lupus study took part. Researchers tracked side effects, serious health events, and ch…

This study tested whether taking probiotics (good bacteria) can help people with active lupus. 40 adults with lupus took probiotics to see if it reduces disease activity and flare-ups. The goal was to improve gut health and control the immune system, potentially leading to longer…

This study tested an experimental daily pill, GLPG3667, in 186 adults with active systemic lupus erythematosus (SLE). The goal was to see if the drug could reduce lupus disease activity better than a placebo over 32 and 48 weeks. Researchers also monitored safety and how the body…

This study tested a new drug called cenerimod in 105 people with active lupus. The goal was to see if it safely lowers certain immune cells (lymphocytes) that play a role in lupus. Participants took the drug or a placebo for up to 12 weeks while continuing their usual lupus medic…

This study tested whether a daily coenzyme Q10 supplement, added to standard lupus treatment, could improve disease activity and cell health in children with lupus. Sixty children aged 6-16 with moderate to severe lupus took either the supplement or standard care alone for 3 mont…

This study tested an experimental pill called enpatoran in 456 adults with lupus (SLE) or lupus affecting the skin (CLE). Participants took the drug or a placebo for 24 weeks while continuing their usual treatments. The goal was to see if enpatoran safely reduces skin rashes and …

This study tested a drug called belimumab in children aged 5 to 17 with active lupus. The goal was to see if adding belimumab to their usual treatment could better control the disease. The trial measured how many kids had less lupus activity after one year. Belimumab is not a cur…

This study tested whether hydroxychloroquine, a medicine used for malaria, can slow down or prevent lupus in people who show early signs of the disease. 187 participants with mild symptoms and positive antibody tests were randomly given either the drug or a placebo. Researchers t…

This study tested a non-invasive device that stimulates the vagus nerve to see if it can reduce fatigue in people with lupus. 75 participants with stable lupus and fatigue used either an active or sham device for short and long periods. The main goal was to measure changes in fat…

This study tested a program to help African American adults with lupus manage stress. Thirty participants learned stress-reduction techniques, and researchers measured their stress levels and quality of life. The goal was to see if this approach could reduce stress and improve we…

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) across five Gulf countries. Researchers collected information on patient backgrounds, treatments, and quality of life to better understand the disease and its long-term effects. The goal wa…

This study looked at how a protein called type 1 interferon, which is overactive in lupus, changes the way the body adapts to exercise. 55 adults with lupus were randomly assigned to a 12-week high-intensity aerobic exercise program. Researchers measured changes in fitness and fa…

This study looked at how well people with active lupus follow their treatment plan. Researchers measured blood levels of hydroxychloroquine in 307 patients to see who was skipping their medication. The goal was to understand how common non-adherence is, especially in patients wit…

This study looked at whether a computer-based decision-aid could help people with lupus and their doctors make better treatment choices together. Nearly 1,900 adults with lupus from several clinics took part. The main goal was to see how many eligible patients actually used the t…

This study looked at B cells (a type of immune cell) from 30 people with non-active systemic lupus erythematosus and compared them to B cells from healthy volunteers. The goal was to find gene activity differences that might explain lupus. No treatment was given; this is a pure o…

This study looked at medical records and visited about 600 adults with moderate to severe systemic lupus erythematosus (SLE) to track how active their disease was over time. Researchers measured disease activity using a standard score called SLEDAI-2K. The goal was to better unde…

This study looked at how systemic lupus erythematosus (SLE) affects breathing, physical activity, and tiredness. Researchers compared 50 lupus patients with healthy volunteers using lung function tests, a 6-minute walk, and questionnaires. The goal was to find early signs of lung…

This study tested a short training for rheumatologists to help them focus on each patient's individual needs, aiming to reduce unconscious bias. Researchers looked at whether this training improved the quality of care for Black and lower-income patients with conditions like lupus…

This study looked at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compared their blood cells, genes, and environmental exposures to find clues about why one got sick. Over 1,000 people took part, inclu…

This study looked at 50 pregnant women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) to see if changes in microRNAs (tiny molecules that control genes) during pregnancy are linked to disease activity. Researchers collected blood, urine, and placenta samples…

This study tested a care management program for 35 adults with lupus who were at high risk for emergency room visits or hospital stays. The program assigned a nurse manager to help patients get better outpatient care and stick with their appointments and medications. Researchers …

This completed study looked at information from 1,000 people with lupus to understand the challenges they face. Researchers reviewed existing data, talked with doctors, and built agreement among experts on how to improve patient care. The goal was to identify gaps in diagnosis an…

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…