STAGE IV PANCREATIC CANCER AJCC V8

This study tests a new drug (BMS-986340) plus standard treatments for advanced pancreatic cancer that has spread or returned. About 43 adults will receive the combination to see if it's safe and shrinks tumors. The goal is to find a better way to control this aggressive cancer.

This study tests whether giving a higher dose of radiation can help people with locally advanced pancreatic cancer live longer. Participants must have already had 4-6 months of chemotherapy. The trial compares the higher-dose radiation to standard care, which may include more che…

This study tests a drug called pemigatinib in people with advanced or metastatic pancreatic cancer that has certain changes in the FGFR gene. The drug aims to block these abnormal genes and stop tumor growth. About 40 adults will take part entirely from home using telemedicine. T…

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced or treatment-resistant solid tumors, including pancreatic cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 49 participants will take part in t…

This study is testing a drug called talazoparib in people with advanced solid tumors that have specific DNA repair gene mutations. The goal is to see if this PARP inhibitor can shrink tumors or slow their growth, even in patients who have already tried a similar drug. About 36 ad…

This early-phase study tests a new treatment for people with advanced pancreatic cancer that has a specific KRAS G12D mutation. The treatment uses tiny particles called exosomes to deliver a molecule that blocks the cancer-driving gene. The study aims to find the best dose and ch…

This early-phase trial tests whether adding bosentan (a drug for blood pressure) to standard chemotherapy can help treat pancreatic cancer that can't be removed by surgery. About 21 adults will take part to find the best dose and check for side effects. The goal is to see if this…

This study tests a new approach for people with pancreatic cancer that cannot be surgically removed. It combines a light-activated drug (verteporfin) with an immunotherapy (pembrolizumab) and standard chemotherapy. The goal is to see if this combination can shrink tumors better t…

This study tests whether adding a targeted drug called panitumumab to standard chemotherapy can help people with a specific type of advanced pancreatic cancer (KRAS wild-type) live longer. About 94 adults whose cancer has spread or can't be removed will receive either chemo alone…

This study tests a treatment called HIPEC for people with pancreatic cancer that has spread to the lining of the abdomen. HIPEC delivers heated chemotherapy directly into the belly during surgery, aiming to kill cancer cells more effectively. The study will enroll 40 adults aged …

This early-stage trial tests whether adding leflunomide (an arthritis drug) to standard chemotherapy (gemcitabine) is safe and effective for people with advanced pancreatic cancer that cannot be removed by surgery. About 19 adults will take part. The goal is to find the best dose…

This study tests a new drug called pegcetacoplan combined with standard chemotherapy (mFOLFIRINOX) in people with pancreatic cancer that has spread to other parts of the body. The goal is to see if the combination is safe and helps control the cancer better, while also reducing d…

This study tests a new way of giving two chemotherapy drugs (gemcitabine and nab-paclitaxel) to people with pancreatic cancer that has spread. The goal is to see if changing the timing of the infusion helps shrink tumors better. About 67 participants will be enrolled, and the stu…

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This study watches 800 people with advanced lung, pancreatic, or colorectal cancer to find different types of cancer-related weight and muscle loss (cachexia). Researchers hope to discover why some patients lose weight differently than others. The goal is to create better, more p…

This study is for people with pancreatic cancer that can be removed by surgery or has spread. Researchers want to see how different drugs change tumor biology by comparing biopsies taken before and after treatment. The goal is not to cure the disease now, but to learn which drugs…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to see how these vessels work, which could help decide if a patient's tumor is likely to respond to certain treatments.…

This early phase 1 trial is studying how the drug OMO-103 affects pancreatic cancer cells in 12 patients with advanced or metastatic disease. The main goal is to see if the drug causes measurable changes in the tumor's biology by comparing tissue samples taken before and after tr…