STAGE IV PANCREATIC CANCER AJCC V8
Clinical trials for STAGE IV PANCREATIC CANCER AJCC V8 explained in plain language.
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New 3-Drug chemo cocktail enters Late-Stage trial for Tough-to-Treat pancreatic cancer
Disease control OngoingThis study is for people whose advanced pancreatic cancer has spread and has a specific genetic change (BRCA1, BRCA2, or PALB2 mutation). It compares a new three-drug chemotherapy combination (NABPLAGEM) against the current standard two-drug combination. The goal is to see if add…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2, PHASE3 • Sponsor: Alliance for Clinical Trials in Oncology • Aim: Disease control
Last updated Apr 04, 2026 00:50 UTC
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Scientists test new drug duo to starve tough pancreatic tumors
Disease control OngoingThis is an early safety study testing a new combination of two drugs for people with advanced pancreatic cancer that has spread. The main goal is to find the safest and most effective dose by giving the drugs to 15 patients and carefully monitoring them. Researchers hope the two …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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Smart switch: can changing chemo Mid-Treatment improve pancreatic cancer surgery success?
Disease control OngoingThis study is testing a flexible treatment plan for people with pancreatic cancer that might be removable by surgery. Doctors will give one chemotherapy combination first, then switch to a different one if the cancer isn't responding well or if side effects are too severe. The go…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Apr 03, 2026 14:42 UTC
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Personalized immune cells tested to fight five tough cancers
Disease control TerminatedThis early-stage study aimed to test the safety and initial effectiveness of a personalized cell therapy called STIL101 for patients with advanced cancers that have spread or cannot be removed by surgery. The therapy involved growing a patient's own immune cells from a tumor samp…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Apr 03, 2026 14:41 UTC
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Early trial tests new drug combo for Tough-to-Treat cancers
Disease control OngoingThis early-stage study aims to find the safest and most effective dose of a new drug, M6620, when given with the chemotherapy drug irinotecan. It is for adults with advanced solid tumors, like certain colorectal, pancreatic, or lung cancers, that have spread or cannot be removed …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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New drug duo aims to stall tough cancers driven by common mutation
Disease control OngoingThis study is testing whether taking two oral drugs together—palbociclib and binimetinib—is better than taking one of them alone for controlling advanced cancers that have specific genetic changes called RAS mutations. It focuses on certain hard-to-treat cancers like low-grade ov…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 27, 2026 12:39 UTC
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New drug duo targets tough pancreatic cancer
Disease control OngoingThis early-stage trial is testing a combination of two oral drugs, binimetinib and hydroxychloroquine, for people with advanced pancreatic cancer that has a specific genetic change (KRAS mutation). The main goal is to find the safest and most effective dose of hydroxychloroquine …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Mar 27, 2026 12:38 UTC
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Doctors use genetic blueprint to fight advanced cancers
Disease control OngoingThis study is testing a personalized treatment method for people with advanced breast, prostate, ovarian, pancreatic, or sarcoma cancers that have spread. Doctors analyze each patient's tumor using genetic and protein tests to understand how the cancer is changing and which drugs…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Mar 23, 2026 15:18 UTC
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Double attack on tough cancers: early trial tests combo for patients out of options
Disease control OngoingThis early-stage trial is testing a combination of two drugs, niraparib and dostarlimab, for people with advanced breast, ovarian, pancreatic, or related cancers that have a specific genetic change (BRCA mutation) and have stopped responding to standard treatments. The goal is to…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Mar 23, 2026 15:16 UTC
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Race against time: study tests which chemo combo helps older pancreatic cancer patients live longer
Disease control OngoingThis study aims to find out which of two standard chemotherapy combinations helps older adults with advanced pancreatic cancer that has spread live longer. It will enroll 176 patients aged 70 and older who have not yet received treatment for their metastatic cancer. Researchers w…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Disease control
Last updated Mar 23, 2026 15:15 UTC
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Sound waves supercharge cancer drugs in groundbreaking trial
Disease control OngoingThis study is testing a new method called sonoporation to see if it makes standard chemotherapy more effective for pancreatic cancer. Sonoporation uses ultrasound waves and tiny bubbles to help more of the chemotherapy drug get into the tumor. Researchers are comparing patients w…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Flemming Forsberg • Aim: Disease control
Last updated Mar 23, 2026 15:15 UTC
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Double attack on pancreatic cancer: can immune drug boost standard treatment?
Disease control OngoingThis study is for people with advanced pancreatic cancer that has spread and who have specific inherited BRCA gene mutations. It compares a standard maintenance drug (olaparib) alone against the same drug combined with an immunotherapy drug (pembrolizumab). The goal is to see if …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 23, 2026 15:14 UTC
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New 'Smart Bomb' drug combo tested in tough pancreatic cancer
Disease control OngoingThis early-stage study is testing the safety and best dose of a new targeted drug, anetumab ravtansine, when combined with other cancer treatments. It is for people with advanced pancreatic cancer that has a specific marker called mesothelin. The goal is to see if these combinati…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Mar 02, 2026 15:28 UTC
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Can At-Home video workouts help pancreatic cancer patients stay stronger?
Symptom relief OngoingThis study is testing whether a safe, home-based strength training program delivered via video calls can help people with pancreatic cancer. It aims to see if this approach helps patients maintain muscle, strength, and quality of life while they are receiving chemotherapy or reco…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Mar 20, 2026 14:47 UTC