Stage IV pancreatic cancer ajcc V8
Clinical trials for Stage IV pancreatic cancer ajcc V8 explained in plain language.
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Can a Two-Drug combo tame Hard-to-Treat pancreatic cancer?
Disease control CompletedThis phase II trial tests whether combining niraparib and dostarlimab can control metastatic pancreatic cancer in people who carry BRCA1/2 or PALB2 gene mutations. Niraparib blocks enzymes that cancer cells need to grow, while dostarlimab helps the immune system attack the tumor.…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase 2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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New cocktail aims to starve pancreatic tumors
Disease control CompletedThis early-phase trial tests two drugs together in 15 people with advanced pancreatic cancer. One drug, calaspargase pegol-mknl, lowers a nutrient that cancer cells need to grow. The other, cobimetinib, blocks a protein that helps cancer cells survive. The goal is to find a safe …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase 1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Experimental combo targets Hard-to-Treat pancreatic cancer
Disease control CompletedThis early-phase trial tested two drugs—binimetinib and hydroxychloroquine—in 34 people with a specific type of advanced pancreatic cancer (KRAS-mutant) that had spread. The goal was to find the safest dose of hydroxychloroquine when used with binimetinib, and to see if the combi…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Vitamin d and malaria drug join forces against pancreatic cancer
Disease control CompletedThis phase II trial tested whether adding paricalcitol (a vitamin D drug) and hydroxychloroquine (an autophagy inhibitor) to standard chemotherapy could help shrink tumors in 10 people with advanced or metastatic pancreatic cancer. The goal was to see if the combination improved …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase 2 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Weight-Loss drug shows promise for pancreatic cancer patients
Symptom relief CompletedThis study tested a drug called telotristat ethyl in 23 people with advanced pancreatic cancer who had lost at least 10% of their body weight. The goal was to see if the drug could help them stabilize or gain weight by reducing bowel movements. Maintaining weight may help patient…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase 2 • Sponsor: Emory University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC