STAGE III PROSTATE CANCER AJCC V8

This study tests whether a shorter course of higher-dose radiation (hypofractionated) works as well as or better than the standard longer course for men with prostate cancer who have had their prostate removed. About 186 men will be randomly assigned to one of the two radiation s…

This study was designed to test whether adding the immunotherapy drug pembrolizumab to standard hormone therapy and radiation could improve outcomes for men with high-risk prostate cancer that hasn't spread. The goal was to see if the combination could eliminate cancer cells more…

This study tests whether men with high-risk prostate cancer can receive treatment tailored to their genetic risk score. Those with a low genetic risk may get a shorter course of hormone therapy (12 months instead of 24) plus radiation, while those with a high genetic risk get an …

This study tests whether giving a combination of drugs (enteric-coated aspirin, rintatolimod, and possibly interferon-alpha 2b) before prostate cancer surgery can help the immune system fight the tumor more effectively. About 12 men with early-stage prostate cancer who are schedu…

This early-phase trial studies whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with rare, aggressive small cell or neuroendocrine cancers of the bladder or prostate. About 15 participants with cancer that has spread will receive the co…

This early-phase trial is testing the safety of combining two cancer drugs—nivolumab and cabozantinib—in people with HIV who have advanced solid tumors. The study includes 8 participants with various cancers that have spread. The goal is to see if the combination can shrink or st…

This study tests a special PET scan called 68Ga-PSMA-11 to see if it can find prostate cancer more clearly than standard scans. About 141 men with prostate cancer that has come back or spread will get this scan. The goal is to see if the scan changes how doctors plan treatment, s…

This study tests whether adding a procedure called vesicopexy (lifting the bladder back to its normal position) to standard robotic prostate cancer surgery helps men regain bladder control faster. About 196 men with early-stage prostate cancer will be randomly assigned to receive…

This study tests a lifestyle program called Watchful Living for Black and Hispanic men with early-stage prostate cancer who are on active surveillance, along with their partners. The program includes coaching calls and nutrition sessions to improve quality of life, physical activ…

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program helps improve quality of life, physical activity, diet, and partner support. About 6 couples will take part t…

This study looks at how daily stress, social support, and healthy habits like exercise and diet affect Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to track their activities and feelings. The goal is to understand how couples cop…

This study looks at how hormone therapy for prostate cancer affects the heart. Researchers will compare three treatment groups: radiation alone, radiation with leuprolide, and radiation with relugolix. The goal is to understand why some men develop heart problems and find ways to…