STAGE III PROSTATE CANCER AJCC V8

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific genetic mutations that affect how cells repair damaged DNA. The trial will enroll about 36 adults with various advanced solid tumors (like breast, ovarian, …

This study is testing whether proton radiation therapy can treat high-risk prostate cancer that has spread to lymph nodes while causing fewer digestive and urinary side effects than traditional radiation. Proton therapy uses precisely targeted beams that deposit most of their ene…

This study is testing if a shorter, more precise form of radiation therapy is as effective as the standard longer course for treating prostate cancer that hasn't spread. Men with localized prostate cancer will be randomly assigned to receive either two treatments of a newer, adap…

This study aims to find out which of two standard hormone therapy combinations is safer for the heart in men with advanced prostate cancer. It will compare leuprolide plus abiraterone acetate against relugolix plus abiraterone acetate in 72 men who are also receiving radiation th…

This study is testing whether a shorter, more intense radiation schedule works as well as the standard longer treatment for high-risk prostate cancer. About 1,200 men will be randomly assigned to receive either 5 radiation treatments over 2 weeks or 20-45 treatments over 4-9 week…

This study is testing whether adjusting radiation treatment plans daily using real-time MRI or CT scans can reduce side effects for men with localized prostate cancer. Researchers will compare this 'adaptive' approach to standard radiation that uses a fixed plan. The goal is to s…

This study compares two types of radiation therapy for men whose prostate cancer has returned or spread to a few spots after initial surgery. It tests if a shorter, more precise 5-treatment course (SBRT) works as well as a longer 20-treatment course, with potentially fewer side e…

This study is testing if adding a drug called niraparib to standard hormone therapy after radiation treatment works better at controlling high-risk prostate cancer that is still in the prostate area or nearby lymph nodes. It will enroll about 200 men. The goal is to see if this c…

This study is for men whose prostate cancer has spread to nearby lymph nodes after surgery. It tests if adding a drug called apalutamide to the usual hormone and radiation therapy can better control the cancer and prevent it from spreading further. The goal is to see if this stro…

This study compares how well patients tolerate two different drug treatments for advanced prostate cancer. Researchers will follow 75 men taking either abiraterone with prednisone or darolutamide alone for one year. The main goal is to see which treatment causes fewer serious sid…

This study is testing whether giving prostate cancer treatment at home is as safe and effective as receiving it in a clinic. Black men with advanced prostate cancer will receive part of their standard treatment at home with remote monitoring. Researchers want to see if home treat…

This study is testing whether taking a high weekly dose of vitamin D can help protect bone strength in older men with prostate cancer who are receiving hormone therapy. Hormone therapy can weaken bones, increasing the risk of fractures and falls. Researchers will compare the bone…

This study is testing a more precise form of radiation therapy for prostate cancer that hasn't spread. It uses real-time imaging to track the prostate's movement during treatment, allowing doctors to deliver radiation more accurately. The goal is to reduce common side effects lik…

This study is testing a new type of imaging scan to see if it can accurately tell whether prostate cancer has spread to nearby lymph nodes. If successful, this scan could help doctors decide which patients truly need to have their lymph nodes removed during prostate cancer surger…

This study is testing if a short course of hormone-blocking pills can make prostate cancer cells 'light up' more brightly on a special imaging scan. The goal is to help doctors see smaller or hidden areas of cancer that have spread, particularly to lymph nodes, in men with high-r…

This study is testing whether wearing special bright white light glasses can help reduce severe fatigue and depression in men with advanced prostate cancer who are receiving hormone-blocking combination therapy. The light therapy aims to regulate sleep-wake cycles and boost mood …

This study is testing whether a 10-week supervised golf program can help improve the well-being of prostate cancer survivors who are undergoing hormone therapy. Researchers want to see if regular golf practice, which involves walking, swinging, and balance exercises, can improve …

This study is testing whether wrapping delicate nerves with a special protective tissue during prostate cancer surgery can help men recover better. The goal is to see if this wrap can reduce common side effects like erectile dysfunction and urinary incontinence after the operatio…

This study is testing whether having a trained peer navigator helps African American men with advanced prostate cancer better understand and go through the process of genetic testing. Genetic test results can be important for choosing treatments, but the process can be confusing.…