SPINA BIFIDA

This study tests a patch made from a newborn's own umbilical cord to repair an open spine defect (spina bifida) shortly after birth. The goal is to close the defect, create more space in the spinal canal, and reduce inflammation. The trial enrolls 15 babies born with this conditi…

This study tests whether a drug called oxybutynin, given directly into the bladder, can improve bladder function in children with spina bifida who have not responded well to oral medication. The goal is to increase bladder capacity and reduce the need for more invasive treatments…

This study tests a 10-week online group program for adults with spina bifida. Participants join weekly video sessions to build self-esteem, social skills, and reduce anxiety or depression. The goal is to improve quality of life and emotional well-being. About 35 people aged 18-75…

This study compares two ways of making ankle-foot braces (AFOs) for people with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury. The traditional method uses a plaster cast, while the newer method uses 3D scanning and printing. Researchers want to s…

This study is testing whether a mobile health app can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury better manage their health and improve their quality of life. About 160 participants aged 12 and older who li…

This study tests a treatment called transcutaneous tibial nerve stimulation (TTNS) for children with spina bifida who leak urine despite using catheters. TTNS uses mild electrical pulses at the ankle to stimulate a nerve that helps control the bladder. Twelve children aged 8-18 w…

This study tests a robotic leg brace (exoskeleton) designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device can assist or resist leg movement during walking. The trial …

This study looks at whether two substances found in urine (TIMP-2 and MMP-2) can help predict kidney damage in people with spina bifida. Researchers will compare these biomarkers with the standard Galloway score, which requires invasive testing. About 50 participants will provide…

This study observes how different enema programs affect bowel control in children and adults with spina bifida. Participants starting a new enema program answer online surveys over one year. The goal is to see which method works better and improves quality of life.

This study uses mild electrical stimulation on the skin of the lower back to measure how well the spinal cord and leg muscles work in 30 children and teens with spina bifida. Researchers aim to better understand movement problems, not to treat them. Participants will have tests o…

This study looks at a special clinic called the Transitional and Lifelong Care (TLC) program, designed for adults with conditions like cerebral palsy, spina bifida, or developmental disabilities that started in childhood. The goal is to see if this clinic helps patients and their…